this post was submitted on 22 Sep 2025
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New research reveals that the DNA switches controlling human finger development originated from genes that regulated fish cloacas 380 million years ago[^1].

"Rather than building a new regulatory system for the digits, nature has repurposed an existing mechanism, initially active in the cloaca," explains developmental geneticist Denis Duboule from the University of Geneva[^1].

The research team discovered this by comparing fish and mouse genomes, focusing on Hoxd genes. When they tagged DNA switches with fluorescent markers, these lit up in mouse digits but in fish cloacas. Deleting these genetic elements using CRISPR-Cas9 disrupted finger development in mice and cloaca formation in fish[^1].

"The common feature between the cloaca and the digits is that they represent terminal parts," notes geneticist Aurélie Hintermann. "Sometimes they are the end of tubes in the digestive system, sometimes the end of feet and hands"[^1].

[^1]: ScienceAlert - Fish Buttholes May Be The Reason We Now Have Fingers, Study Finds

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[–] KoboldCoterie@pawb.social 116 points 3 months ago (3 children)

This is the best out-of-context headline I've read all month.

[–] dohpaz42@lemmy.world 23 points 3 months ago (1 children)

Thank you for not making me the only person to have immediately gone “there” with that title.

[–] LillyPip@lemmy.ca 1 points 3 months ago

Those myocene apes were kinky.

[–] HonoraryMancunian@lemmy.world 7 points 3 months ago

Pairs well with the thumbnail

[–] S_H_K@lemmy.dbzer0.com 5 points 3 months ago

I had to do a triple take to check it it was the Onion Not the Onion or 196... This is some truly crazy shit.

[–] TheTechnician27@lemmy.world 45 points 3 months ago* (last edited 3 months ago)

The Nature article in case you want to skip the pop science and get to the good stuff.

Because Hoxd gene regulation in the mouse urogenital sinus relies on enhancers located in this same chromatin domain that controls digit development, we propose that the current regulatory landscape active in distal limbs was co-opted as a whole in tetrapods from a pre-existing cloacal regulatory machinery.

[–] LillyPip@lemmy.ca 40 points 3 months ago* (last edited 3 months ago) (1 children)

⊂( ͡° ͜ʖ ͡°)☞ >-;;⁠;⁠;€ᐷ

[–] Juice@midwest.social 1 points 3 months ago

This post should be hanging in MOMA

[–] toomanypancakes@piefed.world 34 points 3 months ago (1 children)

What a coincidence, a fish butthole is why I don't have fingers anymore.

[–] Harvey656@lemmy.world 8 points 3 months ago (1 children)

Oh wow, a toe-typer in the wild!

[–] humorlessrepost@lemmy.world 3 points 3 months ago (1 children)
[–] Harvey656@lemmy.world 2 points 3 months ago

That would be quite the articulate shlong.

[–] samsy@feddit.org 23 points 3 months ago* (last edited 3 months ago) (1 children)

This will be a good addition to my "I am so fun at partys"-facts.

[–] crank0271@lemmy.world 9 points 3 months ago (1 children)

How many parties do you get invited to?

[–] samsy@feddit.org 15 points 3 months ago (1 children)

Zero. Cause I'm old. But at least I can talk to the other parents on kids birthday partys.

[–] homesweethomeMrL@lemmy.world 8 points 3 months ago

Well you could until you added this fact. Now you’ll be the “fish-butthole-finger” guy.

[–] panda_abyss@lemmy.ca 20 points 3 months ago (1 children)

I would feel awful finding out I genetically modified a fish to not have a butthole.

That’s fucked up.

[–] Zoomboingding@lemmy.world 14 points 3 months ago

All fun and games until you "I have no butthole and I must poop" some fish

[–] AnitaAmandaHuginskis@lemmy.world 8 points 3 months ago

That's a brand new sentence right there

[–] dumbass@aussie.zone 8 points 3 months ago* (last edited 3 months ago) (3 children)

Wait, so am I supposed to finger fish?

[–] N0t_5ure@lemmy.world 6 points 3 months ago

Is this why Kanye likes fish sticks?

[–] axexrx@lemmy.world 2 points 3 months ago (1 children)

Its the reason you have fingers

[–] dumbass@aussie.zone 2 points 3 months ago

I was born to finger fish!

[–] SkaveRat@discuss.tchncs.de 2 points 3 months ago (1 children)
[–] dumbass@aussie.zone 2 points 3 months ago

Ohh yeah, I was just making sure I was doing it right.

[–] restingboredface@sh.itjust.works 7 points 3 months ago

I love how so much science ultimately boils down to putting creatures in a giant magnet and seeing what lights up.

[–] YurkshireLad@lemmy.ca 6 points 3 months ago

So when I was eating fish fingers as a kid in the uk, what was I really eating???!

[–] Broadfern@lemmy.world 5 points 3 months ago

So holding hands is obscene!

[–] Auli@lemmy.ca 5 points 3 months ago (1 children)

And here I thought me sticking my fingers up fish buttholes was the reason they existed.

[–] drspawndisaster@sh.itjust.works 1 points 3 months ago

I always knew that was my purpose

[–] quick_snail@feddit.nl 4 points 3 months ago

That sounds like something AI would say

[–] ininewcrow@lemmy.ca 4 points 3 months ago (1 children)

I'm looking at my fingertips .... realizing that they could have become something else.

[–] crank0271@lemmy.world 8 points 3 months ago

Talk about a missed opportunity. You could have had ten fish buttholes within reach at all times!

[–] rockerface@lemmy.cafe 4 points 3 months ago (1 children)

Some people, in fact, still have hands growing out of their ass

[–] squaresinger@lemmy.world 3 points 3 months ago

I wonder if opinions are also regulated by the same gene.

[–] InvalidName2@lemmy.zip 4 points 3 months ago (1 children)

Mmmmm, butterfingers are my fave.

[–] quick_snail@feddit.nl 1 points 3 months ago

Is that how they're made?

[–] thenextguy@lemmy.world 3 points 3 months ago

Fish fingers and custard!

[–] Kolanaki@pawb.social 3 points 3 months ago

me walking in with 10 fish on my hands

"OMG you're not gonna beleive this..."

[–] korda@aussie.zone 2 points 3 months ago

I goatsee what you did there.

[–] ohellidk@sh.itjust.works 2 points 3 months ago

Buttfingerer

[–] PattyMcB@lemmy.world 1 points 3 months ago
[–] kryptonianCodeMonkey@lemmy.world 1 points 3 months ago

It's why I have fingers... ( ͡° ͜ʖ ͡°) 🐠