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A therapy that would once have been considered a feat of science fiction has reversed aggressive and incurable blood cancers in some patients, doctors report.

The treatment involves precisely editing the DNA in white blood cells to transform them into a cancer-fighting "living drug".

The first girl to be treated, whose story we reported in 2022, is still free of the disease and now plans to become a cancer scientist.

Now eight more children and two adults with T-cell acute lymphoblastic leukaemia have been treated, with almost two thirds (64%) of patients in remission.

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💀 🗿

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cross-posted from: https://lemmy.ml/post/39956162

What I don't get is why it took them decades to figure this out. Why have they been giving us sugar substitutes without understanding what they have been doing to us? Why were these approved for use in the first place?

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The study authors believe an eruption occurred around 1345, about two years before the start of the pandemic, from either a single volcano or a cluster of volcanoes of unknown location, likely in the tropics. The resulting haze from volcanic ash would have partially blocked sunlight across the Mediterranean region over multiple years, causing temperatures to drop and crops to fail.

An ensuing grain shortage threatened to spark a famine or civil unrest, so Italian city-states, such as Venice and Genoa, resorted to emergency imports from the Black Sea region, which helped keep the population fed.

However, ships that carried the grain were loaded with a deadly bacterium: Yersinia pestis. The pathogen, originating from wild rodent populations in Central Asia, went on to cause the plague that devastated Europe.

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Excerpts in case of paywall; the archive.org link isn't working:

Generative conversational artificial-intelligence systems, such as OpenAI’s ChatGPT, are being used to optimize tasks, plan holidays and seek advice on matters ranging from the trivial to the existential... Against this backdrop, the urgent question is: can the same conversational skills that make AI into helpful assistants also turn them into powerful political actors? In a pair of studies in Nature and Science, researchers show that dialogues with large language models (LLMs) can shift people’s attitudes towards political candidates and policy issues. The researchers also identify which features of conversational AI systems make them persuasive, and what risks they might pose for democracy.

The effects were striking. Conversations favouring one candidate increased support for that candidate by around 2–3 points on a scale of 0–100, which is larger than the average effect of political advertising. Persuasion was stronger when the chat focused on policy issues rather than the candidate’s personality, and when the AI provided specific evidence or examples. Importantly, roughly one-third of the effect persisted when participants were contacted a month later, going against the intuitive critique that the initial shifts were probably volatile and ultimately inconsequential.

The persuasive influence was also asymmetric: AI chatbots were more successful at persuading ‘out-party’ participants (that is, those who initially opposed the targeted candidate) than at mobilizing existing supporters. In the state-level ballot-measure experiment in Massachusetts, persuasion effects were even larger, reaching double digits on the 0–100 scale.

Analysing 27 rhetorical strategies used by the AI models to persuade voters who engaged with them, the team found that supplying factual information was one of the strongest predictors of success... Yet ‘facts’ were not always factual. When the team fact-checked thousands of statements produced by the AI models, they found that most were accurate, but not all. Across countries and language models, claims made by AI chatbots that promoted right-leaning candidates were substantially more inaccurate than claims advocating for left-leaning ones. These findings carry the uncomfortable implication that political persuasion by AI tools can exploit imbalances in what the models ‘know’, spreading uneven inaccuracies even under explicit instructions to remain truthful.

It is important to note that these findings come from controlled online experiments. It is unclear how such persuasive effects would play out in real political environments in which exposure to persuasive AI agents is (often) voluntary and conscious. Such environments also contain a myriad of contrasting messages competing for attention, and users can ultimately decide to avoid or ignore specific information sources.

The Nature paper: https://www.nature.com/articles/s41586-025-09771-9

Somehow I can't find or access the Science paper mentioned by the news article. If someone can find it please comment

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As Fleming's story has significant inconsistancies, a few theories on how penicillin was actually discovered are discussed in this article.

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"That fungus is called Cladosporium sphaerospermum, and some scientists think its dark pigment – melanin – may allow it to harness ionizing radiation through a process similar to the way plants harness light for photosynthesis. This proposed mechanism is even referred to as radiosynthesis."

cross-posted from: https://lemmy.world/post/39553283 https://libretechni.ca/post/483480

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submitted 1 week ago* (last edited 1 week ago) by Tasey@lemmy.world to c/science@lemmy.world
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Another example of institutional investigations conducted in secret, without a public report, for 'privacy reasons'.

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Neutron counts under the Chernobyl sarcophagus rose, but the best evidence says the spike came from shifting moisture inside the wrecked reactor, not an approaching chain reaction.

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