It saved my life essentially I was getting 16 migraines a month now I get zero.
this post was submitted on 24 Jun 2026
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The absolute coolness that is science and stuff amazes me! We saw a deadly poison, studied the shit outta it, now keep it and use it like a pet! It's really neat!
All those glp-1 agonists that are all the rage right now are because scientists recognized the gila lizard can go long periods without eating while keeping its blood sugar stable and studied its venom
The current drugs like ozempic are synthetic though, no actual gila venom
Also fun fact: the guy that discovered the effect figured it out in the early 90s and actually patented it himself because for years no one was interested. Pharmaceutical industry was apparently “disinterested” and it wasn’t moved forward until 2002 (exenatide/byetta, a precursor to more efficacious drugs like tirzepatide/zepbound/mounjaro, which coincidentally made Eli Lilly the most valuable drug company in the world. Another fun fact is that Lilly partnered with another smaller company to make exenatide then Lilly dissolved the partnership in 2011, allowing the smaller company to keep the rights, likely because they saw the opportunity for the next steps)
In my graduate neurology class, we learned how it works and that affected nerves can pass it along to adjacent nerves, disabling them as well. This takes multiple doses over time, so one or two treatments is not a huge concern. The professor then told us how shocked he was to learn that 15 year olds are getting injections.
Not just cosmetic, I believe it’s used to treat migraines and possibly other issues. Crazy stuff.
A few billionths of a single gram in a muscle will kill you. That's fucking nuts that it's used on people.
Dose makes the poison. Even the most toxic substance known to man can have benefits in a small enough dose.
If you ingest antifreeze, the cure is a measured amount of alcohol to counter the effects. The poison of my poison is my cure.
Same with methanol poisoning from tainted or improperly made alcohol beverages . The treatment is to drink proper alcohol beverages.
The poison of my poison is my cure.
It might be controversial to some, but I always thought they were an okay band.
I learned this from the episode of House with LL Cool J
And in some cases it’s essential for brain development and function like iodine.
I was a part of the noburp community on the old site. In the last decade it's been used to cure that. The body metabolizes it after about 6 months, but having that assistance often helps build the muscle memory and people can usually burp after that. I personally had it done twice and can still do small burps at last, and my daughter (toddler, born very prematurely) had it done at the beginning of the year. Her physical medicine doctor mentioned it as a possibility, and when I told him about the burping thing he basically equated Botox in the medical community with Windex in My Big Fat Greek Wedding
It was strange finding out that other people had the same issue
I would strongly suggest getting the treatment if you can! It's a super simple procedure.
R-CPD for those interested in the procedure. I think a doctor in Chicago came up with it?
Pretty much. It affects people differently, but one guy talked to manually any doctor who would listen. Dr. Bastian in Chicagoland has a YouTube channel about laryngology (basically all throat stuff) and that guy who had so many issues with not being able to burp contacted Dr. Bastian about it. He told him to get some Botox on the muscle of the throat that releases gas, and the guy ended up flying to Chicago to have it done. Dr. Bastian is pretty legendary in that community now. He also has a very impressive background even before that.
I actually went to that practice for my first injection and was originally booked to see Dr. Bastian. He fell sick the week I was there, but another doctor in the practice was able to do it instead since I came from out of town. Honestly everyone there is great!
But also, I saw similar symptoms in my toddler daughter, who was very underweight (getting better!). It was hard, because it can be difficult enough to find someone willing to do it for an adult, but a young child? Nobody wants to take that risk. Most specialists I talked to thought it made sense, but it really wasn't their area (fair) or they'd get skeptical. The ENT we saw about it was HORRIBLE and basically chased us out because it was a zebra. Eventually I booked a telehealth visit with Dr. Bastian just to see if I was projecting my own experiences on her, and he was the kindest man. Sent a letter with his opinion for me to show other providers, and I think it really helped show I wasn't insane.
Daughter eventually had it done by a pediatric ENT doctor who has done it before. She did great for several days but snapped back after an endoscopy about a week later. We're trying again in about a month and a half!
Sorry to ramble, but this has been such a big thing for me personally!
Yes! It can be used to treat paralysis in the digestive tract too. It's crazy what a little poison can do 😉
The estimated human median lethal dose of type A toxin is 1.3–2.1 ng/kg intravenously or intramuscularly, 10–13 ng/kg when inhaled, or 1 μg/kg when taken by mouth
fuuuuuck thats... terrifying.
One microgram per kg? Jesus fucking Christ
The intravenous one is 3 orders of magnitude lower. μg is 10^-6^. ng is 10^-9^.
NANOgram when iv
Fuck that's crazy, its lethal dose by mouth is LSD's standard dose by mouth 😂
Swiss-American veterinary scientist, created a center at the Hooper Foundation in San Francisco, where he developed techniques for growing the organism and extracting the toxin, and conversely, for preventing organism growth and toxin production, and inactivating the toxin by heating. The California canning industry was thereby preserved.