Maybe we could get menopausal people into the DIY estradiol scene. Like breaking bad but it's some middle aged person cooking estradiol solutions in an instant pot.
this post was submitted on 01 Jan 2026
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Prostate cancer hasn't been cured yet... steve jobs died early... it's not that simple.
Pretty disingenuous to compare cancer, one of the most heavily studied medical conditions on the planet, to this. Just because there's no cure to being made of cells? It's not that simple.
I'm uninformed, but isn't cancer largely a mammalian feature?
That's a good question. I don't know for sure. I just meant to imply that thinking about cancers in terms of "cures" isn't a very useful way to approach the matter.
A cursory search suggests that reptiles and birds do get cancer, just at a noticeably reduced rate. Maybe something to do with metabolism? Or a side effect of bodies capable of live birth? Dunno.
I've also heard that whales and elephants get less cancers than we would expect from animals (or I guess mammals) of their size.
steve jobs died early
Not a good example. He had an extremely curable form of cancer and chose to try a fruitarian diet instead of going to doctors, until it was too late.
The fruitarian diet might have even been worse than ignoring it entirely, with the sugars basically "feeding" the cancer.
? There are treatments for osteoporosis. They're called bisphosphonates. And bone density screenings are routine in older women. Am I missing something?
the existence of treatments doesn't mean they are readily available to people who need them.
But that's because your healthcare system doesn't really exist, and that's true for just about everything
Don't know why you're being downvoted. Many male doctors are sexist as hell. So unless you know there are treatments and bring it up and/or force the issue, the doctor isn't going to tell you.
You're just not hating on men the right way.
To be fair this is more industry specific than just motivated by some sense of misandry.
It's specifically doctors. And medicine is still biased as fuck.
Rich men would invest in their own bones, the rest of us would die even earlier than women do.
On the other hand, men on average live shorter, and we just go "well it's just risky behavior and physical labor I guess 🤷♂️" and they're aren't any task forces for that either, truth is we as a society don't care enough about these issues regardless of sex
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Aging should be studied a lot more. I believe once the AI bubble pops, the computing power and models should be applied to biology. How do ageless atoms become old meat? I want to know, as an old meat myself, and if we can treat, stop, or even reverse the process.
AI/ML has already been used to study protein folding and I'm sure it'll be used to study other facets of biology too. There's great use cases for the tech once you look past the tell-mentally-ill-people-to-kill-their-families-bots.
I may be wrong but I think one hard part is identifying the places where ML makes sense to use. Need people who understand biology AND ML for that.
Most of the stuff known as AI in the current environment is really, really powerful inference engines. And understanding the limits of inference (see for example Hume's Problem of Induction) is an important part of understanding the appropriate scope of where these tools are actually useful and where they're actively misleading or dangerous.
So, take the example of filling in unknown details in a low resolution image. We might be able to double the number of pixels and try to fill in our best guesses of what belongs in the in-between pixels that weren't in the original image. That's probably a pretty good use of inference.
But guessing what's off the edge of the picture is built on a less stable and predictable process, less grounded in what is probably true.
When we use these technologies, we need domain-specific expertise to be able to define which problems are the interstitial type where inferential engines are good at filling things in, and which are trying to venture beyond the frontier of what is known/proven and susceptible to "hallucination."
That's why there's likely going to be a combination of things that are improved and worsened by the explosion of AI capabilities, and it'll be up to us to know which is which.
Exactly. AI/ML absolutely has useful use cases, it's just not a complete solution for literally anything.
There's a number of different reasons but the hardest to overcome is the fact that we evolved to grow old and die. Having an upper limit on our reproductive age positively benefits our ability to keep evolving and having an upper limit on total age balances the benefits of age (wisdom and experience) with the need to not deny the younger generations of resources.
How do ageless atoms become old meat? I want to know, as an old meat myself, and if we can treat, stop, or even reverse the process.
Atoms must arrange themselves in a particular way to become a cell. A cell knows how to make copies of itself, but sometimes mistakes can happen. Like a game of telephone, the cell at the end of the line only knows how to make a copy of itself, not how to make a copy of the original cell it came from. The mistakes gradually accumulate over time, which causes improperly formed cells to accumulate over time and give the appearance of "aging".
In theory, aging is a condition that is surmountable. There are jellyfish that are swimming in the ocean right now that are functionally immortal. They create perfect copies of their DNA every single time, and can repair damage to cells without leaving a trace of the original injury. If we could figure out the processes that allow them to do this, it could be applied to the human genome as well.
Part of the problem is telomerase being lost. The downside is that it's a cancer prevention mechanism, so messing with it (by adding more) is bad news.
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