this post was submitted on 04 Dec 2025
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Science Memes

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[–] TrickDacy@lemmy.world 9 points 5 hours ago

Wouldn't that just be fentanyl?

[–] SeductiveTortoise@piefed.social 28 points 8 hours ago

I mean... it wouldn't really surprise me that much at this point.

[–] Corkyskog@sh.itjust.works 14 points 7 hours ago (2 children)

You can actually use Nalaxone as a base to make an opioid, I think Oxymorphone if I remember right.

[–] dickalan@lemmy.world 6 points 6 hours ago (1 children)

Historical myth: The rumor started in the 1990s–2000s on drug forums (and later persisted on places like Reddit) because people noticed the close structural relationship and assumed “just swap the side chain.” In reality, pharmaceutical companies start from opium-derived precursors (thebaine → oxycodone → etc.) or full total synthesis — they never use naloxone as a starting material to make oxymorphone.

[–] Corkyskog@sh.itjust.works 7 points 5 hours ago (1 children)

Well of course pharmaceutical companies don't, they can get cheaper base materials for opioids like the thebaine you mentioned. It was just someone proving it could be done and showing that it could be a potential concern one day. Right now it's a million times easier to get and cook fentanyl with precursors, so no one would bother with this synthesis. It's not like consumer nalaxone is cheap for the amount you get.

[–] moody@lemmings.world 3 points 3 hours ago (1 children)

I dunno, I can go to the pharmacy right now and get naloxone for free if I wanted. They give that shit away here.

[–] Corkyskog@sh.itjust.works 4 points 3 hours ago

4 mg at a time... I think they might get suspicious after your 100th time.

[–] SinAdjetivos@lemmy.world 5 points 6 hours ago

A lot of opioids are fairly related, Oxycodone and Oxymorphone can be used as precursors to make Nalaxone and vice versa. I recall Four Thieves Vinegar Collective doing a similar trick though I don't remember what the actual precursor was.

[–] D1re_W0lf@piefed.world 4 points 6 hours ago

I misread “sarcasm” and was worried for a second.

[–] ameancow@lemmy.world 3 points 6 hours ago* (last edited 6 hours ago)

I almost wrote out a joking idea about mandatory injections of live, healthy viral cultures that all children are required to get for "natural, effective immune system development" but I didn't want to give the fuckers the idea.