this post was submitted on 21 Mar 2026
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Global News

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The largest review of medicinal cannabis to date found it doesn’t effectively treat anxiety, depression, or PTSD—despite millions using it for those reasons. Researchers warn it could even make mental health worse, raising risks like psychosis and addiction while delaying proven treatments. Some limited benefits were seen for conditions like insomnia and autism, but the evidence is weak. The findings are fueling calls for stricter oversight as cannabis use continues to rise.

Study: https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(26)00015-5/fulltext

Archived version: https://archive.is/newest/https://www.sciencedaily.com/releases/2026/03/260319044656.htm


Disclaimer: The article linked is from a single source with a single perspective. Make sure to cross-check information against multiple sources to get a comprehensive view on the situation.

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[–] WraithGear@lemmy.world 2 points 5 hours ago

i don’t recall that weed was ever used for those things, other then just as a copeing mechanism, i think the argument is that it was better then the other narcotics by a country mile.

unless you are talking about charletons, but like we got people saying magic rocks cure cancer so like why would we need to validate their nonsense?

[–] Kwakigra@beehaw.org 4 points 11 hours ago

There aren't any drugs that resolve anxiety, depression, or ptsd on your behalf with nothing else. The most any drug can do is reduce feeling these things while they're active so that the causes of the feelings may be addressed with lifestyle and cognitive changes.

Drugs are a temporary shelter from the raging storm of these issues while you re-build or build up in the first place a real shelter to experience the world from in peace and comfort. The temporary shelter blows away when the drugs wear off, and to rely on a temporary shelter permanently is no solution. That being said, plenty of people without any shelter at all don't survive. Drugs help, but they don't fix the problems they provide temporary relief from, you must solve those problems.

Like the study said, there needs to be more specific research in a controlled environment of these substances being used in coordination with established therapies and procedures. I have personal anecdotal experience of positive outcomes with cannabis in a robust framework addressing these issues beyond chemical means. Importantly, I may not have survived without the option to put the overwhelming desire to opt out of this planet on hold for a few hours at a time by briefly regaining my ability to feel pleasure. My psych wanted to try ketamine for this purpose, but I'm a lot more comfortable with cannabis.

[–] etherphon@piefed.world 3 points 13 hours ago

Well this study doesn't mention psychic pain or spiritual warfare so it's clearly hogwash.

[–] rants_unnecessarily@piefed.social 18 points 20 hours ago* (last edited 20 hours ago) (1 children)

It's not a "cure" medicine, it's a "relief" medicine.

Like painkillers.
They don't heal, they help lessen the negative effect of the illness to help while healing.

We already know this, stop twisting study results to sound like there's no positive side of cannabis.

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[–] olafurp@lemmy.world 11 points 19 hours ago* (last edited 19 hours ago)

To be fair, the population of this meta analysis is severely underpowered to assess whether there is an effect for rare/semi-rare conditions. (population is couple of hundred in most areas) and it shows in the confidence intervals. Wouldn't exactly call this a "huge" study.

A better title would be "Study unable to determine if cannabis helps or hurts anxiety, depression, or PTSD because of lack of data" which sounds less glamorous.

[–] mountainbear49@programming.dev 8 points 20 hours ago

Fascists have been robbing people at gunpoint in their own homes with approval from a serial killing billionaire monopolist state and that article talks about pseudoscience, non-verifiable, self-report based terms like feelings of anxiety, depression, and PTSD. Facts have shown that POVERTY causes anxiety, depression, and PTSD. POLICE STATE ARMED ROBBERIES CAUSE ANXIETY, DEPRESSION, AND PTSD. They're more likely to happen to people on the antagonist side of the MERCK, PFIZER, GSK MONOPOLY DRUG CARTEL. That is a fact about cannabis possession, cultivation, usage, and sale. Another relevant fact about this study would be the shadow network of BIG PHARMA serial killers with residence addresses somewhere near readers of that article and bank accounts in 0-tax jurisdictions of the likes of Panama, Luxembourg, etc. that funded putting that pile of feces into a format that looks like a scientific article. In the meantime, those unethical bastards have been selling drugs of the likes of opioids, benzodiazepines, etc. from inside hospitals near the readers of that article, drugs that have killed tens of thousands if not millions of humans per year.

P.S. That article totally omits to even acknowledge the variety of types of cannabis with widely different molecular composition profiles.

P.P.S. That article also omits to acknowledge that fact that research on cannabis consumption therapy has been happening outside the fascist states of the american-european colonial (and racist) empire and their ‘universities’ (sites of propaganda) because of a little thing called a decades-long illegal criminalization of the non-violent behavior of personal choice of consumption of a plant flower with numerous therapy applications growable with a small budget in approximately any house.

[–] GreenBeanMachine@lemmy.world 3 points 17 hours ago

FUCK YOUR PATHETIC PROPAGANDA!

[–] Legendz662@lemmy.world 3 points 18 hours ago* (last edited 18 hours ago)

Here we go with them trying to keep the lies going & sadly a lot will fall for this again but that's why they legalized it so they could lace it for more future problems

[–] ryannathans@aussie.zone 33 points 1 day ago* (last edited 1 day ago) (10 children)

There were six studies included on anxiety with a total participant count of ~350... What a pathetic attempt of a review

Only 123 participants for PTSD and ONE study included

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[–] MantisToboggon@lemmy.world 51 points 1 day ago (2 children)

It doesn't fix anything, you just don't care as much.

[–] DarrinBrunner@lemmy.world 36 points 1 day ago (5 children)

Right, this does depend on the criteria for successful treatment.

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[–] UnderpantsWeevil@lemmy.world 22 points 1 day ago* (last edited 1 day ago) (1 children)

"Huge study reveals ibuprofen doesn't eliminate pain, just the sensation of it"

Oh okay, I guess I should stop using it then?

"Well, maybe... We need to do another Huge Study to confirm"

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[–] bearboiblake@pawb.social 46 points 1 day ago (2 children)

Weed helped me not kill myself while going through a mental breakdown with the most severe traumatic flashbacks and dissociative episodes I have ever experienced in my life. I wipe my ass with this study.

[–] The_Almighty_Walrus@lemmy.world 4 points 19 hours ago

Same, if it wasn't for weed I probably would have punched my own ticket years ago. I've been off it for a few months studying for a drug test and yaboi needs a bong rip.

[–] fiat_lux@lemmy.world 51 points 1 day ago* (last edited 1 day ago) (14 children)

It's not the study that's the problem here, the study clearly examined it "as the primary treatment". This is a common science media failure, they've conflated "primary treatment" with "helps", and that is not the same thing at all.

Crutches aren't the "primary treatment" for a broken leg either, but they do assist recovery by allowing someone to not use the broken leg. I'd suggest cannabis plays a similar role, it gives people the distance from the pain and further injury that they need for actual recovery, which sounds like it could describe your experience.

[–] CaptainSpaceman@lemmy.world 3 points 22 hours ago

Cannabis is sychoactive and allows for deeper introspection to anyone attempting to reconcile their mental health.

It may not be a panacea, but it is very much a great tool in the arsenal of mental health.

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[–] turdburglar@piefed.social 23 points 1 day ago (2 children)

well, that’s just like, their opinion, man.

And didn't pass peer review

[–] rosco385@lemmy.wtf 13 points 1 day ago (1 children)

I don't think weed helps my anxiety, but it does help with the side effects of the anti-anxiety medication.

[–] Maeve@kbin.earth 1 points 13 hours ago

It helped my anxiety. But I don't need it anymore, anyway.

[–] Omgboom@lemmy.zip 20 points 1 day ago

I mean this is obviously anecdotal, but it helped me tremendously through some of the worst trauma I have ever encountered. I don't really give a shit what any study says.

[–] nutsack@lemmy.dbzer0.com 0 points 13 hours ago (2 children)

smoke a weed, feel euphoria for 10 minutes, then crippling anxiety for 4 hours

worst drug ever thanks

[–] Aneb@lemmy.world 2 points 13 hours ago

As soon as I started an effective dose of Prozac my high anxiety went away, in both senses of 'high' (weed high and a lot of anxiety).

[–] Obi@sopuli.xyz 1 points 12 hours ago

Strange because it's the exact opposite for me, I'll get a huge peak of death-fearing anxiety with a quick onset, especially if I do a bit too much, but then it mellows out within 20/30min.

[–] Iconoclast@feddit.uk 4 points 1 day ago

I was about to come tell how that has not been my experience at all but then I realized I read the headline wrong.

[–] Laser@feddit.org 15 points 1 day ago (4 children)

Was cannabis ever a serious contender for these issues? I always considered a painkiller and against loss of appetite, but nothing psychological.

delaying proven treatments

Good luck getting treatment for depression here in a timely fashion, I think with the latest changes, people need to wait about a year for an appointment. Situation is bleak, can't blame anyone getting a bit of relief

[–] apotheotic@beehaw.org 2 points 1 day ago

I think the point is that if it is the treatment given to you by your doctor without it being a stopgap, then that is delaying proven treatments. If you use it as a stopgap then that's beside the point

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[–] Kuori@hexbear.net 9 points 1 day ago (2 children)

sure but the planet is dying and i'd prefer not to be sober the whole time

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[–] Kalothar@lemmy.ca 10 points 1 day ago (1 children)

Here’s the findings and interpretations from the paper

Findings

54 trials were identified for inclusion (2477 participants; 1713 [69%] males, 764 [31%] females; median age 33·3 years [IQR 28·1–38·05; ethnicity data not available). 24 (44%) of these trials had a high risk of bias, and the certainty of evidence for most outcomes was low. Our meta-analysis revealed that a combination of cannabidiol and delta-9-tetrahydrocannabinol reduced cannabis withdrawal symptoms (SMD –0·29, 95% CI –0·57 to –0·02) and weekly grams of cannabis use (–1·00, –1·69 to –0·30) among those with cannabis use disorder, and a reduction in tic severity among those with tic or Tourette's Syndrome (–0·68, –1·03 to –0·34) compared with placebo. Any cannabinoid type led to an increase in sleep time as recorded by an electronic device (0·54, 0·14 to 0·95) and sleep diary (0·55, 0·01 to 1·09) among those with insomnia. There was a reduction in autistic traits (–0·36, –0·66 to –0·07) among those with autism spectrum disorder. Cannabinoids led to an increase in cocaine craving among those with cocaine use disorder (0·69, 0·22 to 1·15) compared with placebo. There were no significant effects on outcomes associated with anxiety, anorexia nervosa, psychotic disorders, post-traumatic stress disorder, and opioid use disorder. There were insufficient data to meta-analyse studies of ADHD, bipolar disorder, obsessive-compulsive disorder, and tobacco use disorder. There was an absence of RCT evidence for the treatment of depression. Meta-analysis revealed higher odds of all-cause adverse events (OR 1·75, 95% CI 1·25 to 2·46) among those using cannabis versus control group (NNTH=7) but no higher odds of serious adverse events or study withdrawal.

Interpretation

There was some evidence that cannabinoids can reduce symptoms of cannabis use disorder, insomnia, tic or Tourette's syndrome, and autism spectrum disorder, but the quality of this evidence was generally low. Cannabinoids were associated with a greater risk of any adverse events but not of serious adverse events. Overall, there is a crucial need for more high-quality research. Given the scarcity of evidence, the routine use of cannabinoids for the treatment of mental disorders and SUDs is currently rarely justified.

[–] rants_unnecessarily@piefed.social 7 points 1 day ago (1 children)

Overall, there is a crucial need for more high-quality research. Given the scarcity of evidence, the routine use of cannabinoids for the treatment of mental disorders and SUDs is currently rarely justified.

I think this is the main conclusion here.

[–] olafurp@lemmy.world 2 points 19 hours ago

Yeah, even the ones where an effect was found have a very low GRADE score (framework for assessing whether conclusions of studies should be used as guidelines) that is affected by risk of biases, directness of evidence, consistency and publication bias.

[–] dohpaz42@lemmy.world 10 points 1 day ago

Well, speaking for myself, it most certainly helps with my anxiety and depression. So they can stuff it for all I care.

[–] LainTrain@lemmy.dbzer0.com 0 points 15 hours ago* (last edited 15 hours ago)

Yeah some people need to hear this but just cuz it grows out of earth don't make it medicine.

Weed just ups your heart rate, makes you hungry and eventually makes you kinda sleepy when it wears off. It doesn't help with much of anything except draining your wallet and time into getting lung cancer.

Now real drugs might help, from SSRIs to Benzos to Amphetamines, a dash of Nicotine, maybe even psychedelic therapy with the HT2A receptor classical psychs class. That's real medicine.

Weed is the opium of the masses.

[–] bulwark@lemmy.world 9 points 1 day ago (4 children)

And might I ask who is funding this study and how are they being paid for by big pharma?

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