Semaglutide has been prescribed to diabetics for 20+ years now. Asking for the horror stories is probably unreasonable fear mongering. So many topics have horror stories, which if followed directly, would indicate staying away from the thing. Unless it's an unusually high percentage of people experiencing negative effects it's mostly medical denialism, eg anti Vaxxers, to focus on the slim chance of problems. I've had two surgeries in the last two years, one of the side effects was death, people do die during surgery, I'm fine. I'm still recovering but I'm getting there.
this post was submitted on 01 Mar 2026
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There is currently no known off ramp for the drug. This really isn't that big a deal for people who are using it to treat diabetes, some conditions are not cured and simply managed with medication, but it is concerning for people who are using it casually for weight loss, as it's so often egregiously advertised.
There is no off ramp for other diets either. You stop, you gain weight.
This, it isn't a magic drug that permanently changes you.
If you don't change your underlying lifestyle then things will go back to how they were.
This is obvious to anyone that bothers to think about it for even a second.
I stopped my see-food diet and lost weight.
Most of the risks are caused by rapid weight loss and not eating properly, not the medication itself.
Something like 0.2% of people have vision problems, up to complete vision loss. This might be strictly correlated to those people being diabetic and already headed for vision problems anyway.
I have been using retatrutide for about half a year now. Very positive overall health benefits. The only downside for me is occasional quite bad constipation.
Ooo, I've got one!
Last Saturday, I was knocked off my feet with a stomach virus.
Because the meds slow down your digestion, it was difficult to, um, expel the illness in the usual, fast manner. I started feeling slightly better on Wednesday, but the issue wasn't really resolved until Friday morning.
Oooo! That is very interesting 👀 glad you’re feeling better!
Biggest thing (from what I understand) is that losing weight too rapidly will result in significant muscle loss. Losing muscle also lowers your metabolism, which can lead to rapid weight gain when you get off the drug.
This isn't glp-1 drug specific, and can be offset by exercise, eating more protein, etc.
Also, rapid weight loss could cause issues with your gall bladder.
there was a ChubbyEmu video about that recently.
I’ll have to look it up! I’ve never heard of a chubby emu! Only chubby bunny!
Oh man, if you like strange and stupid medical stories then you are in for a treat.
Gpl 1s slow down your bodies natural digestion process and send the signal that you’re full. One problem is when it goes too far and your body almost stops digestion.
I saw an article about one person who wound up having rotting food sitting in her stomach causing her to vomit it out.
O lord that is foul
I’ve heard that dosages are way higher than necessary. Body builders are using gray market product with approaching 1/2 the dosage and seeing good results I think I remember someone saying.
I take one for diabetes, and my dose is 1/3rd to 1/4th the typical dose prescribed for weight loss.
There seems to be an anorexia fad. People who didn't even need to lose weight now look anorexic after taking it. Feels like we're back in the 90's. Baggy pants, midriff shirts, and being incredibly incredibly thin.
This reminds me a lot of eye surgery which I was kinda paranoid about. Thing is there is no way to really know about long term effects until something has been around a long time.