Joe Pera Talks To You

Going for the more obscure: Bajillion Dollar Properties. Originally made for a dead streaming service, now exists on PlutoTV for free (and can be purchased through Apple et al). It's a satire of real estate reality shows with phenomenal guest stars throughout. Main cast includes a few folks before they got their bigger roles (like Tawny Newsome, Drew Tarver, and Eugene Cordero) but also includes the GOAT, Paul F. Tompkins.

Very related, I would also suggest the Comedy Bang! Bang! TV show that ran for 5 seasons on IFC. It's a treasure trove of comedic goodness, lots of great guests, and who doesn't love Reggie Watts, Kid Cudi, then Weird Al as the band leaders??

How to with John Wilson, 30 Rock, Malcolm in the Middle, The Office, Nathan for You, Parks and Rec, Joe Pera Talks to You, Ted Lasso, Baskets (LOVE it, but can be a little sad and heartbreaking in addition to being hilarious and sweet)

Recently I watched and enjoyed Parks and Recreation and One Day at a Time (netflix series). Light hearted engaging content. Another recommendation: Schitt's Creek.

Parks and Recreation. So funny. If you like the office you’ll love it!

'Ghosts' on CBS/Paramount+ is sweet, funny, lighthearted for the subject matter, and overall very enjoyable. I don't think it will win any awards, but its a great alternative to all the dark and cynical stuff out there!

Scrubs

Upload

It's Always Sunny?

On the surface, it contains terrible people doing terrible things, but it's both comedic and condemns those terrible things

Pushing Daisies.

Letterkenny

If you're a weeb there's an entire genre of this stuff: iyashi-kei ("soothing type/genre"). I've enjoyed a bunch of them, though some of them get pretty saccharine if that's a worry. There's a large overlap with "slice of life", and a lot of these are set in school for whatever reason - YMMV. I like Azumanga Daioh, though the anime adaptation is a little aged. Nichijou is adorable and leans more into absurdism if that's your thing. "Yotsuba&!" is freaking precious, but manga only - same guy as Azumanga Daioh.

For non-weeb stuff I'll mention Brooklyn Nine-Nine, also Parks and Recreation once it hits its stride.

The Great North, if you want to watch a fun and wholesome cartoon.

Lots of good suggestions so far, but not seen The Great mentioned. Filthy AF and one of the few shows I laugh out loud to (well, more like cackle loudly). I'll also second the suggestion for Better Off Ted.

Trailerpark Boys

Close Enough.

Frasier

It is cancelled now, but Last Man on Earth is such a great show.

Bee and puppycat

It's only one season, but Wonderfalls. It's pure joy. And all the episodes are on Youtube.

Letterkenny

Schmigadoon!

It's very light-hearted and campy. Well, at least the first season is.

The Last Man on Earth

I'd highly recommend Avenue 5.

Broad City is pretty light-hearted

Red Oaks

Awkwafina is Nora From Queens

Obscure show, but watch Traffic Light on prime.

Community Great British Baking Challege (in US, it's Bake-off everywhere else) Brooklyn Nine Nine Thirty Rock And seriously, The Golden Girls

Just started watching Deadbeat, doesn't take itself seriously and I'm laughing most of the time. Easy watching.

Doc Martin