It’s probably not a problem… probably

Chingada madre!

(Jackie, Cyberpunk 2077. See you in major leagues, my dear friend)

I don't remember the exact line, but in Metal Gear Rising: Revengence they say something to the effect of "Just like the WMDs and Iraq!" Referring to how the US used a lie as a false pretext for invasion. It was just so straightforward and direct. Even today that would still be crazy, but that game has been out for a while. Pretty bold to put it in.

And remember, bad times are just times that are bad.

"Here come the test results: 'You are a horrible person'. That's what it says, 'a horrible person'. We weren't even testing for that!"

It's a-me, Mario!

From Assassin's Creed 2. Might be known from some other game too, I dunno.

"I'm going to the one place capitalism hasn't corrupted yet... Space!"

Hello, my name is Dr. Glenn Pierce, and by now you may have realized that all of this has happened exactly the way it was supposed to. You see, everyone who comes to the institute does so because they feel they are no longer in control of something important to them. But, more often than not, the problem is not that the problems we face can't be solved; the problem is that we become so afraid of failure that we refuse to see our problems from a new perspective -- and so we do the same things again, and again, and again. And therein of course, we find exactly the failure we were looking for.

Your life will always be a struggle, and you will always have problems. But today, you had the chance to see things differently. Even though it meant facing obstacles that seemed impossible at first, you thought outside the box - and you overcame them. Because you saw things from every angle, you understood them for what they really were. Because you kept moving forward, no matter how far off the path you were told you were headed, or how unexpected it became...you found your way.

In a few minutes, you'll be back in the real world, and some part of you will say that none of this was real: So how could it have meant anything? But -- just like the power of perspective itself -- it will have been as real as you believed it to be. All you've got to do is... wake... up.

There's no shame in it, Raziel - revenge is motivation enough. At least it's honest. Hate me, but do it honestly.

"The right person in the wrong place can make all the difference in the world" - Half Life 2

The creepy gait of his voice gives me goosebumps every time.

Anything Glados from Portal 1/2--still one of very, very few games to actually make me laugh. But also the Cave Johnson "when life gives you lemons" rant comes to mind, because it's both funny and poignant.

"death will not save you from me"-diablo

Problem: Seems like the point of this game is victory. The absence of defeat on all fronts. Victory in business ventures and creative undertakings. Victory in love and over other people. Political victory. Ideological victory. Hell, even sexual victory. Definitely a lot of object-based victories, too - having things and not losing them. One problem, though: not a lot of victors in sight. Everyone’s mostly losing. Why is that? And how do you not lose?

Solution: How not to lose? It is impossible not to. The world is balanced on the edge of a knife. It’s a game of frayed nerves. You’re pushed on by numbers and punitive measures: pain, rejection, and unpaid bills. You can either play or you can crawl under a boat and waste away - turn into salt or a flock of seagulls. Your enemies would love that. Or you can fight. The only way to load the dice is to keep on fighting.

"What kind of idiot are you?"

"I dunno. The good kind?"

Bulletstorm.

War... war never changes.

"(while looking into the mirror) Despite everything, it's still you.", from Undertale.

Also a bunch of lines from the Happy Happy cult members in Earthbound.

"Damn, I look GOOD" Duke Nukem.

Wololo.

All your base are belong to us.

Statement: I see you have purchased me, master. I find this a satisfactory arrangement. Am I to accompany you now? Shall I kill something for you?

HK-47 from Knights Of The Old Republic is probably my favorite source of quotes: https://starwars.fandom.com/wiki/Wookieepedia:Quote_of_the_Day/Archive/HK-47

• I was most proud to have partaken in the political system of the galaxy. During the time [the senator] possessed me, he gained significant rank. Given enough time, I believe he could have become chancellor. I even eliminated a few key opponents that he did not ask for. Freebies, if you will.
• Query: Would you rather be caught with contraband that is very illegal or just a little illegal?
• Droids tend to blend into the background, like a bench or a card table. Mockery: Droid, fetch this. Droid, translate that. Droid, clean out the trash compactor. Part of the love of my function comes when the ‘furnishings’ pull out tibanna-powered rifles and point them at the owners' heads.
• Observation: I am a droid, master, with programming. Even if I did not enjoy killing, I would have no choice. Thankfully, I enjoy it very much.

Had to be me. Someone else might have gotten it wrong.

You must construct additional pylons.

Words to live by.

This always stuck with me. From Braid. Particularly the bonded paragraphs. I added the whole section for completeness.

Tim is off on a search to rescue the Princess. She has been snatched by a horrible and evil monster. This happened because Tim made a mistake.

Not just one. He made many mistakes during the time they spent together, all those years ago. Memories of their relationship have become muddled, replaced wholesale, but one remains clear: the princess turning sharply away, her braid lashing at him with contempt.

He knows she tried to be forgiving, but who can just shrug away a guilty lie, a stab in the back? Such a mistake will change a relationship irreversibly, even if we have learned from the mistake and would never repeat it. The princess's eyes grew narrower. She became more distant.

Our world, with its rules of causality, has trained us to be miserly with forgiveness. By forgiving too readily, we can be badly hurt. But if we've learned from a mistake and become better for it, shouldn't we be rewarded for the learning, rather than punished for the mistake?

What if our world worked differently? Suppose we could tell her: 'I didn't mean what I just said,' and she would say: 'It's okay, I understand,' and she would not turn away, and life would really proceed as though we had never said that thing? We could remove the damage but still be wiser for the experience.

Tim and the Princess lounge in the castle garden, laughing together, giving names to the colorful birds. Their mistakes are hidden from each other, tucked away between the folds of time, safe.

Had to be me, someone else might've gotten it wrong.

All your base are belong to us.

"GET OVER HERE!"

"The thing about happiness is that you only know you had it when it's gone. I mean, you may think to yourself that you're happy. But you don't really believe it. You focus on the petty bullshit, or the next job, or whatever. It's only looking back by comparison with what comes after that you really understand, that's what happiness felt like."

-Conrad Kellogg; Fallout 4.

"I don't think I can forgive you for that."

"...but I'd like to try."

Lots of good bioshock quotes, but the standout:

We all make choices, but in the end our choices make us

GET UP ON THE HYDRA'S BACK

A man chooses, and slave obeys.

I’m here to kick ass and chew bubblegum. I know it’s from a carpenter film, but I heard it first in Duke Nukem.

Everything that lives is designed to end. We are perpetually trapped... in a never-ending spiral of life and death. Is it a curse? Or some kind of punishment? I often think about the god who blessed us with this cryptic puzzle... and wonder if we'll have the chance to kill him.

"I'm here to kick ass and chew bubblegum, and I'm all outta gum" from Duke Nukem (originally from the movie "They Live").

"Nah" -System Shock 2

"This is the min.... THIS IS THE WARSHIP KUUN-LAN"

I don't want this life...

I don't know if its my favorite, but man it hits hard hearing that.

What is a man? A miserable little pile of secrets.

0.000% of Communism has been built. Evil child-murdering billionaires still rule the world with a shit-eating grin. All he has managed to do is make himself sad. He is starting to suspect Kras Mazov fucked him over personally with his socio-economic theory. It has, however, made him into a very, very smart boy with something like a university degree in Truth. Instead of building Communism, he now builds a precise model of this grotesque, duplicitous world.