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Got a pretty bad case of food poisoning last month. Didn't really eat anything for a couple of days.
My SO had it worse. She was throwing up almost everything she ate for over a week. After about 4-5 days, I was like. I'll drive you to the emergency myself, but I can't force you to go.
She ended up waiting like three more days after that and calling her primary care physician.
She's mostly better now but it was the worst I've ever seen her.
For better or worse, she did lose a decent amount of weight during that week+ of being sick.