this post was submitted on 02 Mar 2026
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Hi, im an insufferable cannabis and science nerd, chiming in:
Your reaction to edibles is based on the amount of cytochrome p450 enzyme that you have in your liver. When you combust cannabis, the thc is converted to delta9thc which is what gets you high. It's why you cook weed before you eat it. When you eat weed and process it through your liver, it then converts to hydroxy11thc, by means of enzymes, and you digest it, which is why it takes longer to feel high from edibles and why it feels different from smoking.
Everyone has different levels of enzyme. Some people will not get high from edibles. Some people will get high from 5mg. I eat about 300mg before I can feel anything other than sleepy. I drank a 1000mg "canna-lean" syrup once, that's the highest I've ever been, it was fun, but I didn't lose my faculties.
I'm not saying tolerance doesn't play a part, but there are other factors. Also if you're primarily vaping, THATS what you should take a break from. Our cannabinoid receptors did not evolve alongside such highly concentrated thc products, they aren't used to getting slammed with 85%+ thc, it's used to like 10-12% found naturally in landrace strains. You're system is burned out. The biggest scam in the legal industry is the way they market "30% thc!" as a good thing. The big number sells more weed, so that's all the businesses care about, but cannabinoids and terpenes and INDIVIDUAL BODY CHEMISTRY have way more to do with how you're gonna feel that high. I prefer a 13-17% thc content that is balanced with thcv, cbg, etc, but the market doesn't care about providing you a good product, they just want your money.
Anyway, that was a whole lot of unsolicited information, here's a source about the enzyme ⬇️ have a great day, stay lifted ♡
https://en.wikipedia.org/wiki/11-Hydroxy-THC