this post was submitted on 24 Sep 2024
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It's not for me. I don't know why, but it makes me loopy. With beer, your liver builds a tolerance to it over time and your mind learns to not say certain things when under the influence. With weed, that tolerance is 100% mental as far as I can fathom, and I'm just too weak-willed under its influence apparently.
The tolerance isn’t totally mental, it just takes longer to build and recede than alcohol does.
To each their own though, not trying to pressure anybody.
where does the tolerance come from though? With alcohol it's very clear that there's one organ doing the heavy lifting. With weed, I have no idea.
Of course! Likewise, I'm not trying to shame anyone for picking weed over beer. Each to their own
Edit: Apparently it's "CB1 receptor density" in your brain that handles the tolerance.
Indeed, a lot of drugs that are non toxic have tolerance created in the brain, while more toxic drugs have to get processed by the kidneys and liver, which is why the functioning of those organs contributes to tolerance.
It’s not your liver, it’s your GABA receptors downregulating that gives you a tolerance. Your liver helps with the duration and hangover but the lower peak intoxication is mediated by the receptors. Likewise with cannabis, your THC receptors downregulate to give you a weed tolerance. It is also processed by the liver.