ccunning

In an extremely odd case, a single 79-year-old patient was granted early access to Eli Lilly’s powerful, still-experimental obesity drug retatrutide through the Food and Drug Administration’s “compassionate use” program—raising immediate questions if that sole patient is President Donald Trump, according to a report by Stat News.

Lilly’s retatrutide is a highly anticipated next-generation obesity drug that targets GIP and glucagon hormones in addition to GLP-1. It is currently in late-stage trials to treat obesity, diabetes, sleep apnea, and other conditions. Data from a Phase 3 trial that Lilly released in May indicates that patients with obesity (but without diabetes) who took the drug for 80 weeks lost 28 percent of their weight, an amount comparable to bariatric surgery.

Millions of Americans with obesity are eager to get the drug, with options being limited so far to enrolling in a clinical trial or trying to obtain it by dodgy methods.

But according to a barebones public notice and Stat’s sources, a single person has been granted early access through the expanded access, aka “compassionate use” pathway, which is typically used to grant access to patients with a “serious or immediately life-threatening disease or condition” and who are not able to enroll in a clinical trial, often because they are too ill.

The access request was first made in April, when the person was 79 years old (Trump turned 80 on June 14). It was made by a senior clinician at the National Institutes of Health named Ranganath Muniyappa, who requested it on behalf of a patient with refractory obesity, obstructive sleep apnea, and pulmonary hypertension, which is high blood pressure in the lungs. Sources told Stat this patient had spent a year on tirzepatide, a drug that targets the GLP-1 and GIP hormones. But the patient had achieved only moderate weight loss on the drug.

At first I thought it might be unable to display mods across instances, but then for some communities mods from other instances do display just fine.

Image 1: Voyager shows comm has no mods
Image 2: Same comm in web interface shows there is a mod
Image 3: Voyager shows a comm with cross-instance mods

Seek wasn’t cooperating with an ID.

What’s the best way to deal with them?

ALT Text: Scene is WAITROSE. Behind it is a staff member, whose name we will soon learn is BECKY. She is dealing with a customer, for now out of shot, while talking to her manager on the phone.

BECKY [on phone]: Yeah, hiya...

2 BECKY: Yes I have a customer here who wants to complain about the Easter eggs.

3 BECKY [putting hand over receiver while addressing the customer stood at the desk in front of her]: Sorry what was your name again?

4 [Pull back to show the customer is a very tall, green-skinned, PAGAN GODDESS, festooned with flowers. Stood next to her is her son, a normal human teenager in a hoodie, who looks mortified by his mum.]

PAGAN GODDESS: Eostre the Pagan Goddess of Fertility

5 BECKY Sorry - Your name is Easter…?

PAGAN GODDESS: Eostre.

6

[Vicky pauses, trying to take this in].

VICKY: Your name is Easter and you want to complain about the Easter eggs.

7 PAGAN GODDESS: Sorry love, what’s your name?

BECKY: Becky

PAGAN GODDESS: Well, Vicky -

8 PAGAN GODDESS: If it was you who’d shagged the solar god of the Equinox to give birth to an actual living god - my son Darren here -

TEENAGE BOY: Muuum…

9 PAGAN GODDESS: ….only to have all your efforts totally forgotten by history, you’d have a complaint too!

10 PAGAN GODDESS: Aisle four is full of products, with no hint of the true meaning of the festival!

11 BECKY: You mean… Jesus…?

PAGAN GODDESS: I mean shagging, Vicky.

12 PAGAN GODDESS: Is it too much to see just a little bit of pre-Christian sex in Aisle 4?

"I requested that if Thai ships need to pass through the strait, could they ​assist in ensuring safe passage?" Sihasak told reporters late on Tuesday.

"They responded that ⁠they would take care of it and asked us to provide the names of the vessels that ​would be transiting."

Iran has ​told the United Nations Security Council and the International Maritime Organization that "non-hostile vessels" ​may transit ⁠the strait if they coordinate with Iranian authorities, Reuters reported on Tuesday.

In a post on X, Iran's embassy in Thailand said that passage of the Thai ship reflected the close ties between the ​two countries.

"Friends have a special place," it said.

Senator Amy Klobuchar of Minnesota formally announced her campaign for governor on Thursday with a call for unity and decency in her troubled state, which has been roiled by political violence, President Trump’s immigration crackdown and widespread protests after two killings of Minnesotans by federal agents.

Ms. Klobuchar, a popular Democrat with a history of winning by double-digit margins, has spent nearly two decades in the Senate as a common-sense centrist with a folksy demeanor and a carefully cultivated history of bipartisanship.

Now, with her run for governor, the self-proclaimed “senator next door” is gambling that her message of moving past partisan divides can still work even amid one of the most volatile domestic conflicts of the second Trump administration.

With Tim Cook’s persistent support of the Trump administration and mealy mouthed finger-wagging regarding ICE, consider joining me and others in voting against TIm’s position on Apple’s board of directors.