this post was submitted on 13 Jun 2026
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[–] FreddiesLantern@leminal.space 29 points 13 hours ago (3 children)

Out of the loop here, what about grapefruit?

(I’ve been eating it like it’s fruit so far…)

[–] hildegarde@lemmy.blahaj.zone 24 points 6 hours ago

Oral estrogen. They went and trans'd themselves.

Grapefruit interacts badly with many medications. There are a lot of drugs that warn against having grapefruit while taking them. Oral estrogen is one, and taking hormones is a choice to be yourself far more than anything else.

You're on 196 on Blahaj. If you read something you don't understand 87% of the time its transgender.

[–] d5273@lemmy.world 41 points 13 hours ago (1 children)

Grapefruit is an enzyme inhibitor that blocks clearance of many pharmaceuticals. That's dangerous as it can lead to accidental overdoses despite taking the right dosage.

The person here 'being themselves' needs a 'script to deal with modern society and can't have grapefruit as a result.

[–] TerHu@lemmy.dbzer0.com 7 points 11 hours ago (2 children)

I know that your interpretation is most likely what they meant in this meme.

However, I‘m wondering. Is there HRT that you take orally that could be affected by grapefruit too?
In that case there could be a much more positive interpretation of them being told to just be themselves, and they started HRT to achieve exactly that.

[–] Zron@lemmy.world 2 points 7 hours ago

Ask your doctor or pharmacist if you can eat grapefruit while on medication.

Grapefruit delays the breakdown of medication in the body. Most medication require the liver to break down whatever is in the pill into the actual chemical that will effect your body. So what happens is the original chemical in the meds builds up in your body’s and then the grapefruit wears off and your liver goes nuts making active ingredients, leading to an overdose.

[–] d5273@lemmy.world 3 points 11 hours ago

I'm not following your question... Grapefruit inhibits the breakdown of meds, it's probably important to appropriately dose HRTs over days/weeks or else there could be some problems with the endocrine systems due to unexpectedly elevated levels (e.g. cardio stuff).

[–] Hotstillnasty@lemmy.world 57 points 16 hours ago (1 children)

FYI [https://pmc.ncbi.nlm.nih.gov/articles/PMC3589309/] Many of the drugs that interact with grapefruit are highly prescribed and are essential for the treatment of important or common medical conditions. Recently, however, a disturbing trend has been seen. Between 2008 and 2012, the number of medications with the potential to interact with grapefruit and cause serious adverse effects (i.e., torsade de pointes, rhabdomyolysis, myelotoxicity, respiratory depression, gastrointestinal bleeding, nephrotoxicity) has increased from 17 to 43, representing an average rate of increase exceeding 6 drugs per year. This increase is a result of the introduction of new chemical entities and formulations.

[–] kboy101222@sh.itjust.works 8 points 11 hours ago

Wait, holy shit I think that just explained to me why I'm suddenly "allergic" to grapefruit

[–] JoMiran@lemmy.ml 27 points 16 hours ago (4 children)
[–] Derpenheim@lemmy.zip 34 points 16 hours ago (2 children)
[–] Beehaw_Girl@beehaw.org 1 points 6 hours ago

Make sure the grapefruit is warm and yer man is blindfolded and he has no open wounds in his nether-regions.

[–] BucketBong@p.hobo.social 19 points 16 hours ago (2 children)
[–] NKBTN@feddit.uk 5 points 12 hours ago

I only ever saw that clip once and yet I can remember it with more clarity than most

[–] Fetus@lemmy.world 3 points 12 hours ago

I'll make you feel it.

[–] ButteryMonkey@piefed.social 6 points 12 hours ago (1 children)

If you drink beer and want to try making your own, you can make a beer (I did a cream ale, if memory serves) using crabapple (the little round red ones usually grown ornamentally) and blueberry, and what results is a hot pink beer that tastes like a less acidic grapefruit.

Its a recipe I came up with afaik, but I used 5 lbs crabapple and 3 lbs blueberry to a 5 gallon cream ale base. Everyone who tried it said it tasted like grapefruit.

[–] ChaoticNeutralCzech@feddit.org 1 points 9 hours ago

My meds forbid grapefruit and alcohol...

[–] Zgierwoj@lemmy.blahaj.zone 5 points 13 hours ago

I started liking it just before I went on medication 😮‍💨

[–] SnotFlickerman@lemmy.blahaj.zone 9 points 16 hours ago

I don't, I guess I'm lucky.

[–] lath@piefed.social 5 points 14 hours ago

The problem with grapefruit is that it enhances the effects variably, which can lead to an unexpected overdose.

[–] Kowowow@lemmy.ca 4 points 16 hours ago (1 children)
[–] Broadfern@lemmy.world 23 points 15 hours ago (1 children)

Grapefruit interacts with a lot of prescribed medications

[–] AppleTea@lemmy.zip 17 points 15 hours ago

was wondering if this was also why grapefruit is a fairly common ingredient in cocktails, and found this delightful factoid:

https://en.wikipedia.org/wiki/Grapefruit%E2%80%93drug_interactions

The effect was discovered accidentally in 1989, when a test of drug interactions with alcohol used grapefruit juice to hide the taste of the ethanol.[9][10]