This doesn't seem to be much of a narrative that the post wants it to be...
One, this is a state seat, nothing to do with the federal government.
Second, it's a seat that has been thoroughly blue looks like. GOP hadn't even bothered to run a candidate in over a decade, and then they only got 19% of the vote. The GOP candidate showed 38% this time around, which is actually stronger performance than they had before.
Per an article "have historically supported Democrats at the state and local level, but have shifted toward Republicans in federal elections", this is a continuation. If anything, concerning that this is the strongest GOP result for that seat, even though they still lost...
In terms of special elections, the three that are scheduled are pretty much the only ones we are going to see, and all signs point to 2 going GOP and 1 going democrat, resulting in a 220:215 in favor of republicans. Even if they flipped the two GOP seats then it's 218:217. More resignations/deaths could shift things more, but no more special elections since it's so close to the general election now.
Even if, hypothetically, 10 republicans just up and resigned and the vacancies gave the democrats the majority... then what? They do another toothless impeachment? They shake their head disapprovingly at Trump deploying ICE to strategic polling places?
You'd need to see 2/3rds of the senate be willing to go against Trump before anything could realistically stop the worst of the Trump presidency.

