this post was submitted on 31 Jan 2026
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A Phase 2B trial of 89 adult patients conducted by Melbourne-based MindBio Therapeutics, investigating the effects of microdosing LSD in the treatment of major depressive disorder, found that the psychedelic was actually outperformed by a placebo. Across an eight-week period, symptoms were gauged using the Montgomery-Åsberg Depression Rating Scale (MADRS), a widely recognized tool for the clinical evaluation of depression.

The study has not yet been published. But MindBio’s CEO Justin Hanka recently released the top-line results on his LinkedIn, eager to show that his company was “in front of the curve in microdosing research.”

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[–] rockSlayer@lemmy.blahaj.zone 6 points 1 hour ago (1 children)

Most people talking about microdosing are referring to shrooms (psilocybin), not LSD though

[–] Bademantel@lemmy.world 1 points 59 minutes ago (1 children)

Really? I associate it with LSD. Isn't it more difficult with mushrooms as psilocybin concentration fluctuates? I guess you could extract it. Never really thought about it.

[–] Beacon@fedia.io 1 points 21 minutes ago

The fluctuation doesn't make enough difference to switch between a microdose to a macrodose. But don't depend on the shake scraps at the bottom of the bag, because that stuff actually can vary wildly

[–] Unleaded8163@fedia.io 1 points 47 minutes ago

Why not both?

[–] TheReturnOfPEB@reddthat.com 6 points 2 hours ago (1 children)

I'd have to think that this report is looked unfavorably upon by the machine elves.

[–] PennyRoyal@sh.itjust.works 6 points 1 hour ago

Maybe they should try macrodosing