this post was submitted on 31 Jan 2026
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A Phase 2B trial of 89 adult patients conducted by Melbourne-based MindBio Therapeutics, investigating the effects of microdosing LSD in the treatment of major depressive disorder, found that the psychedelic was actually outperformed by a placebo. Across an eight-week period, symptoms were gauged using the Montgomery-Åsberg Depression Rating Scale (MADRS), a widely recognized tool for the clinical evaluation of depression.

The study has not yet been published. But MindBio’s CEO Justin Hanka recently released the top-line results on his LinkedIn, eager to show that his company was “in front of the curve in microdosing research.”

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[–] Beacon@fedia.io 4 points 9 hours ago (1 children)

The fluctuation doesn't make enough difference to switch between a microdose to a macrodose. But don't depend on the shake scraps at the bottom of the bag, because that stuff actually can vary wildly

[–] bobs_monkey@lemmy.zip 3 points 7 hours ago

Ime the shroom powder is what can kick your ass the most