this post was submitted on 31 Jan 2026
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A Phase 2B trial of 89 adult patients conducted by Melbourne-based MindBio Therapeutics, investigating the effects of microdosing LSD in the treatment of major depressive disorder, found that the psychedelic was actually outperformed by a placebo. Across an eight-week period, symptoms were gauged using the Montgomery-Åsberg Depression Rating Scale (MADRS), a widely recognized tool for the clinical evaluation of depression.

The study has not yet been published. But MindBio’s CEO Justin Hanka recently released the top-line results on his LinkedIn, eager to show that his company was “in front of the curve in microdosing research.”

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[–] rockSlayer@lemmy.blahaj.zone 21 points 1 day ago (3 children)

Most people talking about microdosing are referring to shrooms (psilocybin), not LSD though

[–] kabe@lemmy.world 11 points 1 day ago

Microdosing really just refers to taking sub-perceptual amounts of a given substance. It equally applies to things like THC and LSD as it does to shrooms.

[–] Bademantel@lemmy.world 13 points 1 day ago (2 children)

Really? I associate it with LSD. Isn't it more difficult with mushrooms as psilocybin concentration fluctuates? I guess you could extract it. Never really thought about it.

[–] nullroot@lemmy.world 4 points 1 day ago

Grind it up and put it in pills. The resulting pills will have approximately the same doses

[–] Beacon@fedia.io 5 points 1 day ago (1 children)

The fluctuation doesn't make enough difference to switch between a microdose to a macrodose. But don't depend on the shake scraps at the bottom of the bag, because that stuff actually can vary wildly

[–] bobs_monkey@lemmy.zip 3 points 1 day ago (1 children)

Ime the shroom powder is what can kick your ass the most

[–] JoeBigelow@lemmy.ca 1 points 8 hours ago

I have accidentally BOOMED on the space dust at the bottom of the bag

[–] Beacon@fedia.io 1 points 1 day ago

Yeah microdosing LSD seems crazy to me because it lasts so much longer than shrooms. When I've heard of microdosing it's always been referring to shrooms