There's really only two programs that make moving to Linux very problematic for me, that's Photoshop, and Word.
At least with word I can ultimately just sequester that into a VM, or learn a different document program if push comes to shove (RIP all my workflows for citations and templates).
But PS is pretty much non-negotiable, it needs GPU acceleration of a native environment to run well, and there just aren't any alternatives that can do what PS does — I need real channel support (painting on channels, copying between them per layer, actual alpha support instead of naive transparency) and more. As much as I hate Adobe, PS is one of those tools that I just know intuitively, all the texture or photo manipulation work feels entirely natural, and I just don't think I'm going to find that ever again.
So, if Linux people can get it working through Wine, it's a huge relief that I can finally leave the Microslop ecosystem.