this post was submitted on 20 Dec 2025
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[–] KingOfSuede@lemmy.world 166 points 2 weeks ago (1 children)

Salient points for those who don’t want to read the article, or can’t:

  • The team administered a single shot of E. americana intravenously to mice with colorectal cancer, and it completely eliminated tumors in every treated animal.

  • Caused only short-lived inflammatory effects that resolved within 72 hours

  • Over two months of observation, treated mice showed no signs of organ damage or chronic toxicity.

  • The bacterium are also sensitive to antibiotics, providing intervention options if problems were to arise following treatment.

  • When the mice were later re-exposed to cancer cells, none developed new tumors, suggesting the treatment had triggered long-lasting immune memory.

This holds some real promise, I’m very excited to see what this brings! Kudos to the researchers!

[–] UltraBlack@lemmy.world 18 points 2 weeks ago (2 children)

Mfw bacteria become resistant: 😱😱😱

[–] BuboScandiacus@mander.xyz 14 points 2 weeks ago (2 children)

Still probably better than cancer, no ?

[–] musubibreakfast@lemmy.world 6 points 2 weeks ago

Yes, now you have to shove a live frog up your ass every day or die of colon cancer.

[–] UltraBlack@lemmy.world 3 points 2 weeks ago (1 children)

Multiresistant bacteria are a death sentence in many cases...

[–] IAmNorRealTakeYourMeds@lemmy.world 2 points 2 weeks ago (1 children)
[–] acockworkorange@mander.xyz 1 points 2 weeks ago

In many cases it isn't.

[–] RVGamer06@sh.itjust.works 2 points 2 weeks ago* (last edited 2 weeks ago)

Le epic bacteriophage:

[–] zakobjoa@lemmy.world 65 points 2 weeks ago (4 children)

Just a minute at 2000°C also eliminated all cancer cells in mice.

[–] First_Thunder@lemmy.zip 41 points 2 weeks ago (2 children)

Impact on the remaining cells still requires further studying

[–] Test_Tickles@lemmy.world 21 points 2 weeks ago

It turns out that the witch who turned the prince into a frog was actually curing his cancer not cursing him.

[–] BootLoop@sh.itjust.works 2 points 2 weeks ago

That is outside of the scope of this study however.

[–] MonkderVierte@lemmy.zip 23 points 2 weeks ago (2 children)
[–] bdonvr@thelemmy.club 9 points 2 weeks ago (1 children)

Did we read the same paper? Not a single case of regression after treatment.

[–] XM34@feddit.org 5 points 2 weeks ago (2 children)

They were talking about the downsides of treatment via 2000 °C.

[–] bdonvr@thelemmy.club 5 points 2 weeks ago (1 children)

Yeah so was I. But they're wrong, like I said no specimen had cancer return after the 2000⁰C treatment.

[–] jmill@lemmy.zip 3 points 2 weeks ago

True, but by a different mechanism. Immune memory was not involved in their continued resistance.

[–] MonkderVierte@lemmy.zip 1 points 2 weeks ago

oh, the immune system will remember, all your cells will remember

[–] TypFaffke@feddit.org 21 points 2 weeks ago* (last edited 2 weeks ago)

Ah yes, Thermotherapy

[–] Engywuck@lemmy.zip 2 points 2 weeks ago

I bet I can do the same in under 10 s.

[–] RacerX@lemmy.zip 25 points 2 weeks ago

Awesome!

... we'll never hear about this again.

[–] Konstant@lemmy.world 23 points 2 weeks ago

Getting news from memes is next level.

[–] lurch@sh.itjust.works 21 points 2 weeks ago (2 children)

afraid to ask: did it also eliminate the mice?

[–] ElderReflections@fedia.io 43 points 2 weeks ago (1 children)

What's more, the response wasn’t just rapid but appeared to provide ongoing protection. When the mice were later re-exposed to cancer cells, none developed new tumors

Apparently it made them stronger

[–] ShinkanTrain@lemmy.ml 19 points 2 weeks ago

Please stop praying for my mice, they've become too strong. One of them chewed through the fridge

[–] Manjushri@piefed.social 7 points 2 weeks ago (1 children)

Quite the contrary...

first, it has a natural affinity for the low-oxygen environment inside solid tumors, so within just 24 hours it had increased its numbers by around 3,000-fold, but it also didn't drift over to impact any other healthy organs or tissue. Then it's able to directly kill the growth thanks to toxins it secretes inside the tumor.

At the same time, the bacterial invasion triggered a natural immune response, and the tumors soon became flooded with immune cells – particularly neutrophils, and T and B cells – alongside increases in inflammatory signaling molecules. The combined effect was widespread tumor cell death driven both by direct bacterial action from the foreign gut bug and by the host’s own immune system.

...

Importantly, this mechanism appears to also be highly tumor-specific, with E. americana sticking only to the tumor environment. The researchers believe this selectivity arises from a combination of factors unique to tumors – insufficient oxygen (hypoxia), leaky blood vessels, altered metabolism and locally suppressed immune defenses that allow the bacterial colony to thrive where they are also most destructive.

[–] untorquer@lemmy.world 2 points 2 weeks ago

Shit thats a lot of promising routes of action and modulation.

[–] Deestan@lemmy.world 20 points 2 weeks ago (1 children)
[–] ShinkanTrain@lemmy.ml 10 points 2 weeks ago (1 children)

How do you administer handgun for colon cancer? 😳

[–] Deestan@lemmy.world 7 points 2 weeks ago (1 children)

You shouldn't. The side effects turn out to usually be more harmful than the cancer.

[–] BuboScandiacus@mander.xyz 5 points 2 weeks ago

Skill issue

[–] SaharaMaleikuhm@feddit.org 13 points 2 weeks ago (2 children)

Do I eat frog poop or should I suckle on their anus for best results?

[–] falseWhite@lemmy.world 12 points 2 weeks ago

"when administered intravenously", so you inject their poop

[–] pewpew@feddit.it 1 points 2 weeks ago* (last edited 2 weeks ago)

Neither. Vore time

[–] Luvs2Spuj@lemmy.world 9 points 2 weeks ago (1 children)

If this takes off it could be a great thing for conservation. Frogs are in a lot of trouble!

Sadly I'm not so sure, but I like to be optimistic

[–] untorquer@lemmy.world 3 points 2 weeks ago

If this ~~takes off~~

Leaps off

[–] shalafi@lemmy.world 9 points 2 weeks ago (1 children)

This is my argument for government science budgets.

Headline: Scientists Spend Millions Studying Andean Frog Fucking Habits!

"What a waste!"

What if I told you those scientists were making more frogs to study how they can freeze solid and thaw out? Or how limb regeneration works?

Practically all meds come from science like that.

why are you studying Easter island soil? discovery of Rapamicin and the cell cenesense pathways in human cells.

[–] West_of_West@piefed.social 7 points 2 weeks ago

Gale: Stop licking the damn thing!

[–] NigelFrobisher@aussie.zone 4 points 2 weeks ago

They needn’t worry unless the mouse experimental animal Union is more powerful than theirs.

[–] Asidonhopo@lemmy.world 1 points 2 weeks ago

Could be we just aren't eating enough uncooked whole, live frogs in our modern diet. Someone has to volunteer to gulp down a few to see if their probiotics cure their cancer, throw some newts in for good measure. If we don't get proof that works at a citizen science level, pharma companies will at best brew the bacteria in a lab and sell it back to us at exorbitant prices. Who will be the next Jonas Salk?

[–] thenewred@lemmy.world 1 points 2 weeks ago

:bufo-offers-gut-bacterium:

[–] robocall@lemmy.world 1 points 2 weeks ago

I am down to get some frog gut shots