I'm left handed. I manipulate the mouse (trackball, actually) with my left hand. This means all default controls suck.

Most games are nice enough to include key-bind customization. This is good! A lot of games (including most AAA games) don't extend this to menu controls, including reversing the mouse buttons so I get to pinky-click my way though the main menu.

The best ones are games that feature engines where I can alter the config files and customize my keybinds there. This usually allows me to make it comprehensive.

Some games dont what to differentiate between numpad arrows and the editing arrows (the island). Locking numlodk helps. I'll use Autohotkey to lock down numlock, rebind the numpad enter (to differentiate it from the Return key) and to map the numlock, and scroll-lock islands to letters I can rebind.

Some companies give no fucks, and expect me to use a default controller. Note that controllers are right-handed, so I don't like them. Again, Autohotkey solves this relatively well, or I choose not to bother with that game.

It also raises interface questions. In Thief: The Dark Project walk forward (quiet), sneak forward (very quiet) and run forward (loud) were single buttons. A lot of games make sprinting a chord to forward unnecessarily. (It makes more sense when the sprint modifier affects all directional movement, or as per the awesome button in Saints Row, The Third

I also like a designated grenade button, and will macro select grenade with fire-selected weapon to make one. I may deselect the grenade and select previous weapon in the same macro if I'm feeling fancy. In Left-4-Dead I made heal-other and toss-pills hotkeys to make them second nature.

So yeah, game controls are wierd, and I think it would serve us all to get in the habit of customizing them exactly as we like, to complain about games with rigid controls or sucky schemes, and praise games that are easy to play and don't kill us by interface failure. (see Death by Ladder).