There was a show I remember way back called "Testees" where it followed a couple of guys who were human Guinea pigs for some pharma company. Each episode was generally about some new drug and the horrible/hilarious side effects and shenanigans that would ensue. There was also a 3rd guy who was basically Frank from It's Always Sunny, and the B plot would flow him sometimes. In one episode, the company actually makes a penis enlargement pill that works, however a little too well. It's so big that every time he gets an erection, he blacks out from the drop in blood pressure. Been a while since I've thought of that show lol.