I take fluoxetine. It doesn't have an immediate physical effect like Tylenol, Gravol, and the like. The effect builds up with time. I would describe it as feeling like "quiet". Fluoxetine gave me the ability to quiet bad thoughts. From there, I had more stability to climb out from the pit of despair and anxiety.

The first few days (maybe two weeks or so) after starting, I slept a lot. Where I used to go to bed at 11:30pm and wake up at 5am, I was now out like a light at 8pm. My brain was finally quiet, so I could feel my body's exhaustion.

The next thing I noticed is that I was able to let small annoyances slide. I used to be triggered by stuff like someone playing music too loudly in the bus. Instead of hyperfixating on that sound and ruminating for the entire bus ride, I could now let it fade in the background and think of something else.

After a few weeks, I noticed less crying, less blowing up at my partner, and less panic spirals. That time and energy I could now put into other stuff: chores, hobbies, socializing. I wanted to be happy and I felt empowered to make it happen, rather than at the whim of the exterior world.

While fluoxetine greatly diminished my lows, it also muted my highs. In my manic-ish days I felt "happy" for hours, and often hypersexual. Now my happiness was different, like... instead of going on fun rollercoasters and having my heart race, I was now sitting in a cozy armchair with a cup of tea and a snack, and my heart was peaceful. I do have a lower libido, which is tough on my partner. (OTOH I now contribute a lot more to household tasks, so it events out lol.) I do miss the euphoria I used to be able to feel, but I don't wish it back because I know the price I had to pay for it.