What is Doomer? :(
It is a nebulous thing that may include but is not limited to Climate Change posts or Collapse posts.
Include sources when applicable for doomer posts, consider checking out !bloomer@www.hexbear.net once in awhile.
https://www.reddit.com/r/nursing/comments/1nbc6vi/something_i_never_thought_id_see/
There are only a handful of medical terms that give me a sense of heart-stopping cosmic horror. "Infection Status- Prion Disease Under Investigation" is one of those things I'd hate to see on a ward.
RFK furiously googling "prion disease cull".
"what do prions taste like?"
"do prions make your muscles bigger?"
"can you name your prions?"
"prion vs brain worm who wins"
"prions just very small worms?"
The brain worm eats all the prions. And yet you still get hexbear tankies saying brainworms are bad, smdh my damn head
I've never been in medicine, but I've played Plague Inc. and have come to hate prion diseases, too.
Imagine the best Plague Inc disease. That's CWD.
what's the mechanism how prion disease works, ive heard it explained as prions 'folding' proteins wrong but how does that work chemically?
It's kind of like if cancer was caused by a pathogen. Cancer is just one of your cells mutating and then multiplying that improper copy until it fills your body. With a prion disease, the misfolded protein can't serve the function its intended fold allowed. It then begins reproducing itself, so your brain is full of junk protein. These junk proteins act like we thought Alzheimer's did due to that bullshit study, forming plaques that are neurotoxic to surrounding tissue. When healthy neural cells touch them they die and your brain becomes full of holes.
how does it reproduce itself without RNA though?
Reproduce was the wrong word to use. It's like a zombie. The misfolded protein is really stable which is why it's so hard to eradicate, even surviving sterilisation. It doesn't need energy, it doesn't do anything, it's the lowest energy state for that kind of protein. It acts as a template when interacting with healthy proteins, which aren't as stable because they need to perform some function. The unstable healthy protein is attracted to the stable prion because they're both hydrophobic, like how oil clumps together in water. Once they contact, the prion is able to infiltrate the healthy protein and they form hydrogen bonds that destabilise the original template in the protein. The healthy protein begins folding in the more thermodynamically stable template.
exactly perceptible, thanks so much--the wikipedia article is surely useful to biologists or whatever but i didn't understand that part at all. the stability bit also explains why they aren't 'corrected' by contact with other proteins.
the only thing im left wondering is if this only applies to certain proteins or if they can effect any old protein
sorry for turning your meme post into an impromptu biology lesson lmao 
It really only impacts the nervous system because that's where the highest concentration of vulnerable cells is and neurons don't really divide or recycle like other cells. The neurons are covered in the protein that's vulnerable to prions, with them normally helping to maintain the neuron and boost its signal strength. They would lack the substrate they need in other body parts and your immune system is programmed to defend those cells from anything that looks foreign.
Oh boy a neurological disease I haven't heard of. as someone with MS I am interested in learning about other neuro diseases. I sure hope that searching CJD on the internet does not bring me many results of people with Ms also developing CJD. That would really fuck up the rest of my day.
Originally it was the deer/elk/moose herds in Colorado. They seasonally transition between the Rockies, foothills, and front range beneath them. We built our cities and farms on the front range, our resource industries and houses in the foot hills, and pushed them into hostile mountain territory that was depopulated of their predators. The super unhealthy herds were concentrated and nature took its revenge on us with a nightmare protein that survives in their meat, the soil they interact with, and medical instruments used in treating patients with it. In those Cervidae populations it's chronic wasting disease which is now silently spreading throughout the US, Canada, and Europe. It's asymptomatic for months in them and years in us, eventually presenting as dementia. At some point it's going to make COVID look quaint.
I recognize that it is a prion disease, but I also recognize that my immune system will happily generate anything to attack me.
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