https://www.reddit.com/r/nursing/comments/1nbc6vi/something_i_never_thought_id_see/
There are only a handful of medical terms that give me a sense of heart-stopping cosmic horror. "Infection Status- Prion Disease Under Investigation" is one of those things I'd hate to see on a ward.
It really only impacts the nervous system because that's where the highest concentration of vulnerable cells is and neurons don't really divide or recycle like other cells. The neurons are covered in the protein that's vulnerable to prions, with them normally helping to maintain the neuron and boost its signal strength. They would lack the substrate they need in other body parts and your immune system is programmed to defend those cells from anything that looks foreign.