Although the Strong Heart Study reported a positive association between saturated fat and CVD in younger than in older individuals (ie, RR = 5.17; 95% CI: 1.6, 16.4), the fully adjusted model that included adjustment for polyunsaturated fatty acids, trans fats, and monounsaturated fatty acids was not statistically significant (RR = 2.98; 95% CI: 0.66, 13.6).
This touches upon the theme of yesterday's paper https://hackertalks.com/post/5676721 , that with large data sets the variables and the groupings of correlation are nearly as important as the data itself.