this post was submitted on 15 Sep 2023
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The psychedelic drug MDMA can reduce symptoms of post-traumatic stress disorder, researchers reported in a new study published Thursday.

The company sponsoring the research said it plans later this year to seek U.S. approval to market the drug, also known as ecstasy, as a PTSD treatment when combined with talk therapy.

“It’s the first innovation in PTSD treatment in more than two decades. And it’s significant because I think it will also open up other innovation,” said Amy Emerson, CEO of MAPS Public Benefit Corporation, the research sponsor.

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[–] FlyingSquid@lemmy.world 20 points 2 years ago (4 children)

How many studies have we seen over the years that psychedelics help with all sorts of mental illness and trauma? And there's a couple of states where just mushrooms are decriminalized. It's ridiculous. It's dangerous. Our drug laws need substantial revision.

Fine, you don't think MDMA should be available to the general public. At least let psychiatrists decide whether or not to prescribe it.

[–] ericisshort@lemmy.world 4 points 2 years ago

Anyone else find it weird that MDMA is considered a paychedelic? Its effects have never seemed similar to other psychedelic drugs to me.

[–] Anamana@feddit.de 4 points 2 years ago* (last edited 2 years ago)

I think your last sentence is super important. We shouldn't exclude a pharmaceutical option, just because the general public perceives it as dangerous. As long as science and doctors greenlight it, we should have it as an option.

[–] LanternEverywhere@kbin.social 2 points 2 years ago

100% completely agreed

[–] ryathal@sh.itjust.works -4 points 2 years ago (1 children)

Decriminalization of psychedelics and medical treatment are opposite ends of the spectrum.

[–] qooqie@lemmy.world 9 points 2 years ago (6 children)

So imma explain some shit maybe poorly with what’s been happening in the psychiatric world.

Recently some huge studies have been published showing that what’s really going on in depression or anxiety isn’t neurotransmitter related it’s synapse related. Let me explain. As you go from being a baby to being 25 years old your brain goes from roughly 200M neurons to 100M neurons. Tf how do you not get stupider?? Well bitches it’s because of something called synaptic pruning. This reinforces the good synapses and eliminates useless synapses/neurons. Okay with all that being said for every neuron in your brain you have ~1000 synapses if you’re healthy. In depression or anxiety you have ~500. So they’ve found by stimulating synapses regeneration you can effectively treat depression from its root biological cause. A drug called Auvelity which is extremely new does this and it’s fucking amazingly effective. I’m talking like a week until you’re feeling better.

Now with all that being said, I’m betting the reason these psychedelics work as treatment is because they stimulate axonal regeneration. But they have the side effect of tripping tf out which can backfire and cause retraumatization.

I hope this makes sense or is cool to others, because it’s fucking awesome to me. Tons of people are about to get waaaaay better mentally because of this research.

[–] fear@kbin.social 3 points 2 years ago

Just to add to your point: in PTSD your brain will prioritize certain synapses over others that may help you survive through the trauma, but will result in a continued focus on the trauma after the event has passed. So those ~500 synapses in depressive PTSD aren't just lower than a healthy brain, but they're also the wrong synapses for your current situation. Psychedelics can help you develop new synapses that are more relevant to your current life. As someone who experienced this therapy, it's amazing how quickly it can happen, too. It's a total game changer and should be available to anyone who wants to try it.

[–] catarina@kbin.social 2 points 2 years ago (1 children)

😮 I want to believe your explanation, but it sounds too good to be true.

[–] qooqie@lemmy.world 1 points 2 years ago

It’s very true. I’ve been seeing people get these drug samples for Auvelity (because it’s expensive af right now being so new and all) and they get much better in a week and then sooooo much better after 2 months that you can take them off Auvelity. I’m super excited for everyone to get better

[–] FlembleFabber@sh.itjust.works 1 points 2 years ago

Yeah mate its cool to me nice info

[–] Anamana@feddit.de 1 points 2 years ago

Well written post, thanks.

[–] egonallanon@lemm.ee 1 points 2 years ago

So all these years of rampant drug abuse have been good for me? Take THAT stupid school drug training.

[–] dxc@sh.itjust.works 3 points 2 years ago (4 children)

What do they mean "MDMA, also known as Ecstasy"? Isn't MDMA just one part of Ecstasy?

[–] LanternEverywhere@kbin.social 5 points 2 years ago* (last edited 2 years ago) (1 children)

(EDIT: it's possible that the terms ecstasy and molly may have changed meanings over time)

Nope, ecstasy means MDMA. I'm an old fart out of the scene for a long time, but that's what it meant for the first like decade or two of it's existence. I've heard that at some point it started getting cut with other cheaper drugs, which is part of why people generally don't call what you can get these days as ecstasy, they call it molly. I've heard that it's very hard to get pure ecstasy anymore, apparently the large majority of what's being sold these days is some random mix with ecstasy just being one ingredient in it.

[–] CmdrShepard@lemmy.one 4 points 2 years ago (2 children)

which is part of why people generally don't call what you can get these days as ecstasy, they call it molly.

I think you have that reversed. Molly is supposed to be just MDMA in crystal form while ecstasy is the pressed pill mixed with other stuff.

[–] dxc@sh.itjust.works 1 points 2 years ago

That's what I heard too and why I got confused in the first place. Maybe it's differing around the globe.

[–] LanternEverywhere@kbin.social 1 points 2 years ago* (last edited 2 years ago)

As an old head i can tell you, the word molly didn't even exist until 10+ years after ecstasy became a thing. "Ecstasy" meant MDMA. If you want you can look up articles from the time and you'll see. The meaning of the words may have switched over time, but for the first decade-ish of its existence on the scene the word "ecstasy" meant MDMA. Ecstasy originally was just MDMA, but I can imagine a situation in which the drug called ecstasy started being cut with other stuff, so people had to come up with a new word to refer to the original uncut substance again.

[–] Anamana@feddit.de 1 points 2 years ago

As MDMA is the most crucial part of ecstasy it's commonly used as a synonym. Especially when reporting to an audience who have no drug knowledge whatsoever..