I have the 16 and use NixOS. I haven't had any issues. I'm able to use the fingerprint scanner and all of the function keys do what they're supposed to.
If you're not already aware, there's a nixos-hardware repo with common settings for various devices that you can import. All of the Framework laptops have a module there. Although, if I recall correctly, everything worked fine before I pulled that into my config, so it seems like the hardware scan did a good job making everything just work.