I'm not sure what hardware you're running, but with my motherboard, to get 4x4x4x4 out of a slot requires sacrificing GPU bandwidth from x16 to x8
to get 4x NVMe drives out of a single PCIe slot without bifurcation you need a card that has it's own RAID controller. These aren't cheap (think ~$500) as they are specialty hardware, but it's a hell of a lot cheaper than a whole professional workstation or server.