Ketamine

Fast acting relief from treatment resistant depression. Personally I find ~0.8 mg/kg subcutaneously injected is about the magic dose.

After 20 odd years of living in a fog the first time I used that treatment was like night and day. I had forgotten how trivial most things are without depression. Exercise for example is just "I don't wanna but I know I'll feel better. Ugh fine" instead of something that takes about 3 days to psych up to on a good week.

I find it's very effective for about a week, dropping off over the next month or so. Unsure if lifetime sustainable at a frequency of ~2-3 weeks per dose but definitely useful to put in changes to life that make it easier to handle.

Crazy expensive medically though, if you can get it tested infusions can be prepared diy (most is diverted from medical supply so it's often not adultrated BUT NOT ALWAYS!) with bacteriostatic water and 0.22 um wheel filters. Obvs if you don't know what you're doing you could seriously harm yourself, and you absolutely must be able to secure safety measures like naloxone, but if the rope is looking mighty appealing it's an option if you can't get it medically.