this post was submitted on 31 Jan 2026
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I somewhat assume you need a macro dose first. Your body needs to understand what the chemicals do.
Then when you microdose your body recognizes the chemicals and refreshed your subconscious memories about the state of mind.
Id love to see some science about microdosing in general, not just with psychedelics.
In my anecdotal experience, when I’ve done shrooms the depression benefits feel like they came not so much from the chemical itself but from the mindset it puts you in. That perspective, combined with the plastic state shrooms put you in has felt the most useful.
It allows you to reevaluate your life and gain perspective on it, while that plasticity actually lets those things stick.
When you microdose sure you might see some of those benefits, but you don’t really enter that altered state of mind where, imo, the real benefits come from.
This is why I think therapy guided sessions are likely the future of psychedelic treatment for mental illnesses like depression.