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Before the twentieth century killing the patient wasn't a big deal, it was kind of expected. Robert Liston, the best (or at least fastest, which for surviving patients was what mattered) surgeon of the nineteenth century, once had a 300% death rate in one of his surgeries (he killed the patient, an assistant, and a spectator) and all the reaction he got was “well, it was a good attempt, try to do better next time”.
Just keep trying until you find a strain that kills less patients than the previous one. They would probably have died from gangrene anyway, so it's not like you're killing them, really, just changing the cause of death. 🤷♂️