this post was submitted on 16 Nov 2025
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Hey trans fems!! I've had my doses for ages, but I've been too consumed with life to worry about trying them. I just got news that my chapter of life is going to be changing soon, and I really wanted to try them during my current stride. So I've decided that just for one day I'm going to give it a shot to see how it makes my brain feel, and I'm going to do a proper two week test run another time. What can I expect from the first day? Any things to be concerned about? Is it possible that this derails my productivity or something strange for the first day?

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[–] lwhjp@piefed.blahaj.zone 5 points 3 days ago (1 children)

As others have said, you're not going to notice anything right away. Why not start taking it regularly and let it cook while you focus on other things? A month or so down the road you'll probably realize you feel better than you ever have and don't want to stop.

[–] CombatWombat1212@lemmy.ml 6 points 3 days ago (2 children)

I wanted to freeze my sperm before starting properly:/ I know it's not 100% likely but I really worry about infertility because I want to have kids someday

[–] dandelion@lemmy.blahaj.zone 2 points 2 days ago* (last edited 1 day ago)

it's smart to worry about infertility and to freeze sperm - I agree with panathea, get on that quick!

however, you should know not only is it not 100% you will be infertile while on estrogen, there's a good chance you will regain fertility if you pause HRT:

https://pmc.ncbi.nlm.nih.gov/articles/PMC9873819/

There is a common untested assumption that this inhibition is permanent, resulting in infertility. In this longitudinal study, we report the recovery of viable spermatozoa in nine trans women who stopped GAHT for reproductive purposes. Our preliminary findings suggest that the negative impact of GAHT on spermatogenesis can be reversed, casting doubt on previous claims that GAHT in trans women inevitably leads to permanent infertility.

sample sizes are small and we can't generalize from such a small group - but it at least falsifies the common belief that HRT will make you permanently infertile, it seems like the opposite is true - that fertility is regained in the majority of observed trans women when they pause HRT.

[–] panathea@lemmy.blahaj.zone 5 points 3 days ago

Yes, get on that!