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Opioid pharma companies were a big cause of the opioid epidemic no doubt, but the government response is what's made it so dire. They just cut a whole bunch of peoples safe opioid supplies, so people could either go into withdrawal, or start using non-pharma drugs. Letting pharma opioids continue what they were doing probably would have, funnily enough, saved many peoples lives.
Over-prescribing painkillers wouldn't be great, but it won't turn catastrophic until someone tries to do a drug crackdown. There's also been a lot of successful anti-opioid propaganda, to the point where I've had friends decide to just bear through the pain rather than accept a 5m oxycodone from the doctor.
I doubt that Tylenol has anything to do with Autism, though. It seems extremely unlikely. And there's still plenty of non-opioid painkillers left after they get rid of Tylenol, Tylenol is just the common one because it's side effects aren't terrible.