this post was submitted on 26 Aug 2025
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Low Carb High Fat - Ketogenic

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Summary


Detailed summary — "The Real Cause of Clogged Arteries and how fasting can help"

  • Core claim: Atherosclerosis (clogged arteries) is primarily driven by chronic inflammation, not merely passive cholesterol deposition, and plaque is a metabolically active, inflammatory process that can rupture and cause heart attacks.

  • Primary triggers that cause vascular inflammation:

    • Metabolic dysfunction (insulin resistance, prediabetes) which promotes harmful lipid profiles including small, dense LDL.
    • Dietary factors (processed foods, high omega‑6 intake, advanced glycation end products) that drive inflammation and oxidative stress.
    • Toxins and impaired detoxification, which increase systemic inflammatory burden.
    • Gut problems (e.g., leaky gut / dysbiosis) that seed inflammation systemically.
    • Lifestyle stressors (poor sleep, chronic stress) that amplify inflammatory cascades.
  • Nature and consequence of plaque: Plaque is described as an inflammatory, metabolically active lesion; when plaque becomes unstable and ruptures the ensuing clot formation leads to heart attacks — so reducing inflammation and stabilizing plaque is central to preventing acute events.

  • How fasting counteracts the causes (mechanisms):

    • Lowers insulin levels, improving insulin sensitivity and reducing production of small, dense LDL, thereby decreasing a major driver of inflammation and atherogenesis.
    • Stimulates autophagy and mitophagy, promoting cellular and mitochondrial cleanup which reduces oxidative stress and inflammatory signaling.
    • Supports detoxification by enhancing liver processing and elimination of toxins that contribute to vascular inflammation.
    • Resets gut health, helping reduce inflammation originating from a leaky or dysbiotic gut.
    • Promotes ketogenesis and fat mobilization during extended fasting, which is framed as anti‑inflammatory and metabolically beneficial.
    • Overall effect: fasting lowers measurable inflammatory markers, improves metabolic health, and creates conditions that can halt or reverse drivers of plaque progression.
  • Practical fasting approaches recommended:

    • Time‑restricted feeding as a daily lifestyle (example: 18:6, eat within 6 hours, fast 18 hours).
    • Periodic prolonged fasts (example: a 3‑day water fast done periodically — cited as helpful for metabolic reset, stem cell mobilization and deeper detoxification; suggested timing varies by individual needs).
    • Use of fasting to achieve ketosis for added anti‑inflammatory and fat‑mobilizing effects.
  • Overall strategy and expectations: Adopt an anti‑inflammatory lifestyle (fasting, improved diet, sleep, stress management, and addressing toxins/gut health) to manage plaque — the goal is usually to prevent progression and rupture rather than promise complete elimination of existing plaque; with these measures individuals can often live with plaque without experiencing fatal events.

  • Takeaway (concise): Targeting systemic inflammation and metabolic dysfunction — with fasting as a central tool among dietary and lifestyle interventions — is presented as the most effective approach to preventing plaque progression and reducing risk of heart attacks.

Dr Jamnadas shares his experience holistically treating patients with heart disease. There is a lot of content, and it's hard to do a write-up when all of it is interesting, so I'd recommend watching the video to anyone who's even at all interested in managing heart disease and staying healthy, since there is a lot of actionable advice.

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[–] xep@discuss.online 2 points 1 day ago

Or does it need periodic fasting?

Based on what I know now, it sounds to me like periodic fasting sufficient to encourage autophagy is a good practice to have in any diet.