this post was submitted on 26 Aug 2025
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Low Carb High Fat - Ketogenic

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Summary


Detailed summary — "The Real Cause of Clogged Arteries and how fasting can help"

  • Core claim: Atherosclerosis (clogged arteries) is primarily driven by chronic inflammation, not merely passive cholesterol deposition, and plaque is a metabolically active, inflammatory process that can rupture and cause heart attacks.

  • Primary triggers that cause vascular inflammation:

    • Metabolic dysfunction (insulin resistance, prediabetes) which promotes harmful lipid profiles including small, dense LDL.
    • Dietary factors (processed foods, high omega‑6 intake, advanced glycation end products) that drive inflammation and oxidative stress.
    • Toxins and impaired detoxification, which increase systemic inflammatory burden.
    • Gut problems (e.g., leaky gut / dysbiosis) that seed inflammation systemically.
    • Lifestyle stressors (poor sleep, chronic stress) that amplify inflammatory cascades.
  • Nature and consequence of plaque: Plaque is described as an inflammatory, metabolically active lesion; when plaque becomes unstable and ruptures the ensuing clot formation leads to heart attacks — so reducing inflammation and stabilizing plaque is central to preventing acute events.

  • How fasting counteracts the causes (mechanisms):

    • Lowers insulin levels, improving insulin sensitivity and reducing production of small, dense LDL, thereby decreasing a major driver of inflammation and atherogenesis.
    • Stimulates autophagy and mitophagy, promoting cellular and mitochondrial cleanup which reduces oxidative stress and inflammatory signaling.
    • Supports detoxification by enhancing liver processing and elimination of toxins that contribute to vascular inflammation.
    • Resets gut health, helping reduce inflammation originating from a leaky or dysbiotic gut.
    • Promotes ketogenesis and fat mobilization during extended fasting, which is framed as anti‑inflammatory and metabolically beneficial.
    • Overall effect: fasting lowers measurable inflammatory markers, improves metabolic health, and creates conditions that can halt or reverse drivers of plaque progression.
  • Practical fasting approaches recommended:

    • Time‑restricted feeding as a daily lifestyle (example: 18:6, eat within 6 hours, fast 18 hours).
    • Periodic prolonged fasts (example: a 3‑day water fast done periodically — cited as helpful for metabolic reset, stem cell mobilization and deeper detoxification; suggested timing varies by individual needs).
    • Use of fasting to achieve ketosis for added anti‑inflammatory and fat‑mobilizing effects.
  • Overall strategy and expectations: Adopt an anti‑inflammatory lifestyle (fasting, improved diet, sleep, stress management, and addressing toxins/gut health) to manage plaque — the goal is usually to prevent progression and rupture rather than promise complete elimination of existing plaque; with these measures individuals can often live with plaque without experiencing fatal events.

  • Takeaway (concise): Targeting systemic inflammation and metabolic dysfunction — with fasting as a central tool among dietary and lifestyle interventions — is presented as the most effective approach to preventing plaque progression and reducing risk of heart attacks.

Dr Jamnadas shares his experience holistically treating patients with heart disease. There is a lot of content, and it's hard to do a write-up when all of it is interesting, so I'd recommend watching the video to anyone who's even at all interested in managing heart disease and staying healthy, since there is a lot of actionable advice.

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[–] jet@hackertalks.com 2 points 3 days ago* (last edited 3 days ago) (1 children)

Bonus points for the star trek cap. Man, this guy talks so slowly. 3x!

One downside of these casual interviews is the studies are not listed for the talking points. Though everything he has mentioned does have a backing study I've seen presented elsewhere. He still pushes some of the common myths around (phytonutrients, fiber, etc) which references would be good to justify... just saying i'm not 100% aligned with his presentation

He doesn't talk about the bart kay turbulence theory

To me the question is a LCHF diet enough for perfect CV health? Or does it need periodic fasting?

The keto-CTA study didn't incorporate fasting as a element. I wonder what the difference would be

[–] xep@discuss.online 2 points 1 day ago

Or does it need periodic fasting?

Based on what I know now, it sounds to me like periodic fasting sufficient to encourage autophagy is a good practice to have in any diet.