Download the mod that allows you to infinite respawns, and explore the outer bounds of the game. I really don't understand the point of the roguelike nature of the game, except to purposely put itself into meme/streamer culture as one of the hardest games ever made.

It's a fuckton better than spending four hours of prep on a run, securing all of the buffs, HP, and weapons to try to figure out some deep lore in some complicated area, only to die to a single pink pixel of Polymorphine. Roguelikes are meant for short and quick playthroughs, not hours-long doomed runs.