Nah, not really. House has 2 episodes where the writers invented diseases (only 2 on the entire run is very respectable though), but more than that, it's not realistic to have 4 docs working on one case all week. And the cases are very unrealistic in the sense that a lot are not mysteries. If you're an MD/DO, you can see some of the diagnoses coming a mile away while House and his team pretend it's a super rare thing. I particularly remember one of the Lyme disease episodes where I got the diagnosis almost immediately, and I was still on med school.

On the other hand, Scrubs gets the lifestyle of an intern right. Except there's a lot less sex in real life lol.