Without sufficient VRAM it probably couldn't be GPU accelerated effectively. Regular RAM is for CPU use. You can swap data between both pools, and I think some AI engines do this to run larger models, but it's a slow process and you probably wouldn't gain much from it without using huge GPUs with lots of VRAM. PCIe just isn't as fast as local RAM or VRAM. This means it would still run on the CPU, just very slowly.