I found a easy way to get SKSE for work for Skyrim and Skyrim Special Edition.
Skyrim
Install Skyrim In Steam
Download SKSE
Open the SKSE compressed and extract the contents into your Skyrim directory.
Go into your Skyrim\Data\SKSE folder and create the SKSE.ini file if there isn't one
Open the SKSE.ini and add the following lines of code into the INI and save the changes
[Loader]
RuntimeName=TESV_SKSE.exe
In your Skyrim folder rename the TESV.exe to TESV.exe.bak
Copy the TESV.exe.bak and paste a copy of it into your Skyrim folder and rename it to TESV_SKSE.exe
Copy the skse_loader.exe and paste a copy of it into your Skyrim folder and rename it to TESV.exe
Skyrim Special Edition
Install Skyrim Special Edition In Steam
Download SKSE
Open the SKSE compressed and extract the contents into your Skyrim Special Edition directory.
Go into your Skyrim Special Edition\Data\SKSE folder and create the SKSE.ini file if there isn't one
Open the SKSE.ini and add the following lines of code into the INI and save the changes
[Loader]
RuntimeName=SkyrimSE_SKSE.exe
In your Skyrim Special Edition folder rename the SkyrimSE.exe to SkyrimSE.exe.bak
Copy the SkyrimSE.exe.bak and paste a copy of it into your Skyrim Special Edition folder and rename it to SkyrimSE_SKSE.exe
Copy the skse64_loader.exe and paste a copy of it into your Skyrim Special Edition folder and rename it to SkyrimSE.exe
Enjoy!