The creators of Skyline just teased their new project named Cassia and showed off some demos such as the Windows version of SuperTuxKart.
What we know so far (subject to change):
It will be an emulator based on Fex-Emu but specifically made from the ground up for Android, it will support 64bits and 32bits programs/games. Cassia will have its own game launcher and a desktop mode.The setup process will be straightforward as the emulator will not use a Linux userpsace and will not rely on Termux like Box64.
Currently, there are several alternatives to run Windows games/programs on Android:
It depends on the soc (mainly high-end snapdragons are compatible due to the help of custom GPU drivers), box64 is the most efficient, but currently none of the methods are straightforward and user-friendly.
Since it's based on Fex-Emu, we should see a better game compatibility but we don't know yet if it will perform better than box64 on Android. I think the end goal of Fex-Emu is to be as good as Rosetta 2 (which is roughly 70-80% native performance).