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The best settings are where everyone is morbidly fascinated by each other.

Humans are effectively viewed as stereotypical frenchmen, constantly smoking and drinking and eating violently stinky food.
Dwarves think asbestos has a wonderful crunchy texture that goes great with a tall glass of mercury.
Elves cannot comprehend why you wouldn't simply drink raw magic like a civilized person (you gotta try some Yith'Illian merlinot, they age it for two hundred years in silverwood caskets which gives it a gorgeous silky texture).
Orcs consider most human food to be ultraprocessed slop for babies, but have become borderline addicted to our hard candy and have formed a deep friendship with dwarves over sharing bones to gnaw on.

In D&D dwarves have resistance to poison damage and advantage on saving throws against poison, so they would be the ones with food no one else could eat safely.

HumanityFuckYeah is a genre that is basically this, although it's most often in a scifi setting.

Usually depicting humans reaching the wider universe and baffling/overcoming large more advanced galactic empires due to Earth effectively being a death world where everything is trying to kill us.

Tbf dwarven religions are like "my ancestors carved these rules with their hands to guide us forward" and elven religions are like "my ancestors got intimate with a fae, starting our race. Also their firstborn is still alive."

Meanwhile human religions are like "here is a horse that's made out of all living beings, with a woman's face too. Mortals who mount it can go to heaven for 5 seconds."

Mythology Reference.

My masturbation has become poison?!?

Seriously. Our bodies are more than half poison, by OP's metric

https://www.nbcnews.com/id/wbna16614865

Elephants eat rotting fermenting apples to get drunk

That was a hoax by some nature documentary channel back then.

...but there is a critter specialized in digesting high amounts of alcohol from fermenting fruits. Also has a boozers nose.

And monkeys do like fermented fruits too.

we have a lot of little superpowers, but i'd say the big one is the thing we're doing right now. We would never have made any of this technology if we didn't communicate and work together absurdly well.

Hell it applies to other animals too: being both intelligent and social unlocks the ability for not only your entire species but potentially even all the intelligent species to collaborate.

The morning necessity is probably caffeine.

But capsaicin is a neurotoxin, and high enough doses absolutely can be dangerous and even fatal. The pain involved long before those doses are reached keeps most sensible people safe.

People beat horses on the regular. The "man vs horse" race balances the course to try to make it equal. Horses will trounce people on courses under 3 hours or so. Humans do better with steep terrain. So humans will crush a trail endurance race over longer distances. We will lose badly on short, flat courses.

Interestingly dogs are the other species that can really hang with people in endurance runs. We will eventually leave them behind as well. They can outrun us in sprints and courses under a few hours. They can't keep pace at 4+ hours.