Shots against seasonal flu, RSV, tetanus, diphtheria, and pertussis (Tdap), pneumococcal infections, hepatitis A and B, and typhoid have all been linked to lower risks. And one of the strongest connections is from vaccination against shingles
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“A central element in this immunological model is that uncontrolled or excessive levels of neuro-inflammation, associated with elevated dementia risk, can be counteracted by epigenetic reprogramming of innate immune cells,” they write.
For instance, it may be that the nonspecific changes to innate responses from vaccines are able to keep both targeted and non-targeted pathogens in check, preventing brain inflammation from flaring up, they say.