Interesting but not directly linked to classic obesity whatever the article tries to suggest in the end, or so I understand it.
this post was submitted on 24 Nov 2025
133 points (96.5% liked)
science
26316 readers
274 users here now
A community to post scientific articles, news, and civil discussion.
dart board;; science bs
rule #1: be kind
founded 2 years ago
MODERATORS
i am thankful my glp-1 provides me significant relief from and control of metabolic disorder. having lost 150 lbs so far it wouldn’t have been possible had i felt the hunger and compulsion to eat. my brain does not see foods the same way as i did prior to my shots. i truly do consider myself lucky and know this will likely be lifelong but am fine with that. i have something that can be treated medically and it is a chronic condition.
if this could at least help shed the weight it could be useful for those on a glp-1 during a stall..? not sure.
I'm all for scientific research and advancement (good on you by the way 👍🏻) but less so on click baity headlines.
If I understood it's directed at genetic disorders linked to the proteins controlling fat storage and usage, and some interesting findings has been, well, found.
Cheers and hang in there!
I expect HSL antagonists to be hitting the unregulated supplement industry pretty quickly. Then we will find that some aren't bioavailable at all and a complete waste of money. But others will be super effective and people will start dropping from heart attacks if their kidneys don't collapse first.
the only reason you should be taking supplements is from a direct recommendation from your doctor who can monitor the levels and have you adjust dosing accordingly. anything outside of that is more likely to do harm than good.
I have a long documented history of ranting against supplements. I am very aware. They often contain things they don't say they do and don't contain what they say they do. That most of it's just expensive of urine. That you shouldn't be taking any supplement unless specifically recommended by your doctor because a blood test showed a deficiency and you should know how to make something you take actually bioavailable. The industry is mostly a scam. And I hate going into health food stores. We're more than half the square footage is supplements. Little pharma is trying to steal your money.
There are so many factors that impact obesity, hunger, eating habits, it’s a tangled web of interaction effects.
Because we fail to think of/treat things holistically, preferring a quick fix of targeting components. Specialized treatment has a place but it's better to integrate it with holistic thinking, if not treatment.
Holistic treatments is diet and exercise. And the people that works for dont take these drugs.
Ahh, I forgot the common vernacular doesn't match what it actually means. I used it in this way: https://my.clevelandclinic.org/health/articles/24103-holistic-doctor
since I often work in health care settings. My fault for failing to remember.
Ah, as in integrative medicine.*
Half of the degrees used by holistic doctors are pseudoscience with little to no evidence supporting them. Chiropracty has proven to be more damaging than helpful and have gotten people paralyzed and even killed.
Yep. That's why I said integrative. Let me be clear: I mean doctors with medical degrees that would consider the diagnosis in relation to sleep, diet, physical and mental stressors, lack of/exercise etc.
I was going based on the article you linked. But I can see a true medical doctor working with and coordinating the patients and their specualist doctors would be valuable.
And proper rest, diet, exercise and managing stressors...
Because we fail to think of/treat things holistically
what specifically do you mean? you think doctors don't tell obese patients to eat better, exercise more, or seek psychotherapy? If so, that's nonsense, of course they do.
A heart specialist may very well tell an obese patient these things, but are they going to spend billable hours that insurance companies deny payment to dig deeper to ask questions and write referrals? Is the primary care team going to fight to get more than six therapy sessions paid? To approve and pay for a gym membership?
if you’re seeing a cardiologist you’re well beyond the point of basic holistic health troubleshooting. that’s something your regular GP handles, THEN if that doesn't help they refer you to a cardiologist for heart specialized care. it would be a waste of your time and money for a cardiologist to be talking to you about anything outside their speciality. that’s the entire reason your have an appointment with them, to focus on specific issues your GP can’t handle.
If you go see a "holistic" doctor for heart problems instead of a cardiologist you're gonna have a bad time.
Lemmy now is what reddit was for me a very long time ago! Thank you for sharing a good article!
Regulatory systems have limits. Some people will have 'abnormal' HSL regulation (now needs considering). For most people, how we live, move and eat can significantly outweight the built in regulatory systems, however well balanced they are.