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I always suspected my antidepressants were messing with my ability to party. (pure.johnshopkins.edu)
submitted 1 month ago by pelletbucket@lemm.ee to c/science@beehaw.org
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[-] theangriestbird@beehaw.org 8 points 1 month ago* (last edited 1 month ago)

this has been known among users of these drugs for quite a while now. They bond to the same receptors, so they interfere with each other. You can mitigate this a bit by going 24 hours without your SSRI/SNRI (ie skipping the dose that would precede the trip), and increasing dose of the psilocybin by ~1.5x. Or so I hear bee mug emoji

[-] 4am@lemm.ee 6 points 1 month ago

Also pretty dangerous to do MDMA without pausing your SSRIs and just about deadly to do them when on MAOIs

[-] theangriestbird@beehaw.org 2 points 1 month ago

true, but MDMA is a different drug

[-] Thann@lemmy.ml 2 points 1 month ago

Yeah, but its a serotonin agonist, so it has a compounding effect

[-] some_guy@lemmy.sdf.org 6 points 1 month ago

Oh yes. Antidepressants have definitely reduced the effectiveness of various drugs for me.

[-] SeaJ@lemm.ee 1 points 1 month ago

Can confirm.

this post was submitted on 18 Jul 2024
29 points (100.0% liked)

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