I've been on SNRI's for a decade +. Venlafaxine, the worst of the bunch. They "work" in that I can feel barely able to live as opposed to definitely wanting to off myself daily. But they disabled my dick and flatten any kind of peak-ey emotions as well, including riding a rollercoaster. If I forget even a single dose - BANG, brain zaps for 12 hours. Good luck falling asleep.
I don't know whether to be thankful they exist or to be sorry I got on them and have to live life like some sort of half-human in the meantime.