Back when I went from 350lbs to 190lbs racing bicycles and commuting full time long distance, my legs turned into lead bricks for 3-4 days after any drinking at all, not just drunk. It messed up everything from sodium uptake to digestive rhythm, to my VO^2^ heart rate zones. That was back in my mid to late twenties too. It isn't just the hangover or age. When you need 4k plus calories per day, bad food habits get amplified sharply. I think everyone is experiencing something like this, but are not aware of the effects for the most part. I dropped out of a race from it once and it added 15-20 minutes to my 1.5-2.0 hour commute each way if I drank.