They are similar in that neither are scientific theories, as they are equally non-falsifiable. We may live in a universe where it is impossible to see the face of god or a glitch in the matrix by construction.

Given that impossibility, how then could you perform an experiment or make an observation that contradicts the theory? To be reductive, science isn't about proving. It's failing to disprove. If there isn't a set of circumstances in which a theory can be disproven, it isn't scientific.

Unless you are a string theorist. Then you just say whatever the hell you want.