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Vaccinations are one of the most cost effective public health interventions.
In the US, the covid vaccine has a sticker price of about $120; which is already a meaningless and overinglated number, but puts an upper bound on the cost of the treatment.
Suppose you are a healthy young adult, working a job earning $15/hour. You do not get vaccinated and end up catching covid. Nothing major, you just call in sick for a day and sleep it off. 8 hours of lost labor at $15/hour gives a lower bound of $120 in economic damages. Of course, your work produces more value then your wage: there is profit, per-employee overhead, non-wage benefits, cost of unplanned disruptions.
Maybe you need 2 days to recover. Now the damages are large enough to have covered at least 2 vaccinations. Maybe you infected someone else, who proceeded to infect someone else. Maybe you value not getting sick at a rate above $0. And this is all just the cost associated with 1 sick day. Some young healthy adults will get even sicker, and there is no way to know ahead of time who they will be.
For covid particularly?