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In my case, the depression etc. turned out to be caused by a chronic inflammation in the gut. No wonder the antidepressants have been working like shit, except amitriptyline because it also does something to the gut.
https://en.wikipedia.org/wiki/Amitriptyline#Other_indications
Doctors have mostly been useless or harmful. I've met one good doctor during the ~30 years I've been ill, and one good nutrition therapist. Thanks to Mistral le Chat (chatbot) connecting some details that humans failed to notice. The treatment is now focused on killing the invading microbes from the gut wall (again), and healing the gut enough so that it can defend itself instead of requiring more and more courses of antimicrobials.